Disease Information for Thrombotic thrombocytopenic purpura: Definition

Ads
  • A disease characterized by thrombocytopenia, hemolytic anemia, bizarre neurological manifestations, azotemia, fever, and thromboses in terminal arterioles and capillaries

    ---------------------------------------

    thrombotic thrombocytopenia purpura; Synonyms of Thrombotic Thrombocytopenic Purpura; One cause of Microangiopathic Hemolytic Anemia

    Moschowitz Disease; TTP; Thrombotic thrombocytopenia purpura (TTP) is a rare, serious blood disease; Major symptoms may include a severe decrease in the number of blood platelets (thrombocytopenia), abnormal destruction of red blood cells (hemolytic anemia), and disturbances in the nervous system; Kidney dysfunction and fever are also common; The exact cause of thrombotic thrombocytopenic purpura is unknown

    ----------------------------------[Nord website 2006]-------

    Thrombocytopenic Purpura Thrombotic thrombocytopenic purpura (TTP) is a life-threatening multisystem disorder that is considered a true medical emergency; Moschcowitz first described TTP in 1924 when he noted that his 16 year-old patient had anemia; petechiae; microscopic hematuria; and at autopsy, disseminated microvascular thrombi; Since that time, the pathophysiology, etiology, and medical management of TTP has expanded; This life-threatening condition may have positive outcomes if recognized early and if medical intervention is initiated early;

    Thrombotic Thrombocytopenic Purpura is a syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever, and renal dysfunction; With the introduction of plasma exchange, the survival rate has improved from approximately 3% prior to the 1960s to 82%

    (Edit)

Ads