Disease Information for Progressive leukoencephalopathy/multifo: Definition

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  • Progressive multifocal leukoencephalopathy is a demyelinating CNS disorder with a propensity for affliction of immunosuppressed adults, especially AIDS patients; The cause is JC virus (JCV), a papovavirus that targets myelinating oligodendrocytes of the CNS; PCR of the cerebrospinal fluid for JCV is used for diagnosis in patients with compatible clinical and radiologic findings; HAART for HIV infection is often effective in improving survival as well as the clinical and radiographic features associated with this disease; Other agents used include cidofovir, not routinely recommended, and topotecan, which appears to be of some benefit; Progressive multifocal leukoencephalopathy (PML) should not be confused with Creutzfeldt-Jakob disease despite the similar initials of the causative agents--------------[Current Medical DX RX 2005]-----------------------------------

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