Disease Information for Primary Myelofibrosis/Myeloid metaplasia: Definition

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  • Myelofibrosis, Idiopathic; Agnogenic Myeloid Metaplasia (AMM); Myelofibrosis and Myeloid Metaplasia; Myelofibrosis-Osteosclerosis (MOS); Myelosclerosis; Osteosclerosis; Primary Myelofibrosis (PMF); Myelofibrosis is a condition characterized by formation of fibrous tissue (fibrosis) within the bone marrow; Bone marrow is sponge-like tissue found within the bones of the body and is responsible for the production of all blood cells (ie, red and white blood cells and platelets); Myelofibrosis may occur as a secondary characteristic to other disorders such as polycythemia vera, certain metabolic disorders, and/or chronic myeloid leukemia; In many cases, the cause of myelofibrosis is unknown (idiopathic);

    In idiopathic myelofibrosis, the ability of the bone marrow to produce red blood cells may be impaired; Symptoms of idiopathic myelofibrosis may include abnormally low levels of circulating red blood cells (anemia), an abnormally large spleen (splenomegaly), an abnormally large liver (hepatomegaly), weight loss, weakness and fatigue due to replacement of normal bone marrow cells, and/or episodes of severe pain in the abdomen, bones, and joints; In many cases, myelofibrosis occurs in association with increased bone density and the formation of small sharp pieces of bone (spicules) within the marrow cavity and increased bone density (osteosclerosis)----------[NORD]--------------------

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