Disease Information for Polymyositis: Definition

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  • Diseases characterized by inflammation involving multiple muscles; This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY, NERVOUS SYSTEM); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders; The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles; The illness may occur at any age, but is most frequent in the fourth to sixth decade of life; Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur; Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response----------- (Adams et al, Principles of Neurology, 6th ed, pp1404-9)-------------

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