Disease Information for Polyarteritis nodosa: Definition

  • A form of necrotizing vasculitis involving small- and medium-sized arteries; The signs and symptoms result from infarction and scarring of the affected organ system;

    commonly caused by chronic hepatitis B; steroid/lamivudin/plasma exchange for viral cause but cyclophosphamide for steroid resistant cases; viral replication increases with just steroid in hep b caes causes eariler cirrhosis; PAN involves skin,kidney,nerves and GI tract preferentially; this is a necrotic vasculitis

    causing renal failure and hypertension