Disease Information for Ornithine Transcarbamylase (OTC) defic.: Definition

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  • NORD COMMENTS:SYNONYMS OF ORNITHINE TRANSCARBAMYLASE DEFICIENCY

    hyperammonemia due to ornithine transcarbamylase deficiency

    ornithine carbamyltransferase deficiency

    OTC deficiency

    DISORDER SUBDIVISIONS

    No subdivisions found.

    GENERAL DISCUSSION

    Ornithine transcarbamylase (OTC) deficiency is a rare X-linked genetic disorder characterized by complete or partial lack of the enzyme ornithine transcarbamylase (OTC). OTC is one of six enzymes that play a role in the break down and removal of nitrogen the body, a process known as the urea cycle. The lack of the OTC enzyme results in excessive accumulation of nitrogen, in the form of ammonia (hyperammonemia), in the blood. Excess ammonia, which is a neurotoxin, travels to the central nervous system through the blood, resulting in the symptoms and physical findings associated with OTC deficiency. Symptoms include vomiting, refusal to eat, progressive lethargy, and coma. NORD 2012 notes

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