Disease Information for Non-steroidal anti-inflammatory drug: Definition

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  • Anti-inflammatory agents that are not steroids; In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions; They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation; They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins; Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects; Certain NSAIDs also may inhibit lipoxygenase enzymes or phospholipase C or may modulate T-cell function-----------------(AMA Drug Evaluations Annual, 1994, p 1814-5)----------------

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