Disease Information for Myasthenia gravis: Definition

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  • A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles; Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles; Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles; The disease may remain limited to the ocular muscles; THYMOMA is commonly associated with this condition;(Adams et al, Principles of Neurology, 6th ed, p1459)--------------------------------Myasthenia Gravis; Erb-Goldflam syndrome; MG ; Myasthenia Gravis Pseudoparalytica; Congenital Myasthenia Gravis; Familial Infantile (Congenital) Myasthenia Gravis; Generalized myasthenia gravis; Ocular myasthenia gravis; Transitory Neonatal Myasthenia Gravis; Myasthenia gravis is a neuromuscular disorder primarily characterized by muscle weakness and muscle fatigue; Although the disorder usually becomes apparent during adulthood, symptom onset may occur at any age; The condition may be restricted to certain muscle groups, particularly those of the eyes (ocular myasthenia gravis), or may become more generalized (generalized myasthenia gravis), involving multiple muscle groups; Most individuals with myasthenia gravis develop weakness and drooping of the eyelids (ptosis); weakness of eye muscles, resulting in double vision (diplopia); and excessive muscle fatigue following activity; Additional features commonly include weakness of facial muscles; impaired articulation of speech (dysarthria); difficulties chewing and swallowing (dysphagia); and weakness of the upper arms and legs (proximal limb weakness); In addition, in about 10 percent of cases, affected individuals may develop potentially life-threatening complications due to severe involvement of muscles used during breathing (myasthenic crisis); Myasthenia gravis results from an abnormal immune reaction in which the body"s natural immune defenses (ie, antibodies) inappropriately attack and gradually destroy certain receptors in muscles that receive nerve impulses (antibody-mediated autoimmune response); [NORD]-----------

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