Disease Information for Multiple Sclerosis: Definition

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  • An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system; Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system; Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction; The usual pattern is one of recurrent attacks followed by partial recovery (MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur--------(Adams et al, Principles of Neurology, 6th ed, p903)--------

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