Disease Information for Mediterranean fever, periodic: Definition

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  • Mediterranean Fever, Familial; ;Armenian Syndrome;Benign Paroxysmal Peritonitis;FMF;Familial Paroxysmal Polyserositis;MEF;Periodic Amyloid Syndrome; Periodic Peritonitis Syndrome ;Polyserositis, Recurrent;Reimann Periodic Disease; Reimann"s Syndrome ;Siegel-Cattan-Mamou Syndrome; Familial Mediterranean fever (FMF) is a rare, inherited, inflammatory disease characterized by recurrent attacks of fever and acute inflammation of the membranes that line the abdominal cavity (peritonitis) and/or the lungs (pleuritis); pain and swelling of the joints (arthritis); and/or the heart (pericarditis) and, in some cases, skin rashes. In addition, some affected individuals may experience a serious complication known as amyloidosis, which is characterized by abnormal accumulation of a fatty-like substance (amyloid) in various parts of the body; If amyloid accumulates in the kidneys (renal amyloidosis), kidney function may be impaired and life-threatening complications may occur; IIn most instances, but not exclusively, FMF affects persons of Mediterranean origin such as Sephardic Jews, Arabs, Armenians, and Turks; FMF is inherited as an autosomal recessive trait; The causative gene on the short arm of chromosome 16 has been cloned; ----------------[NORD]-----

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