Disease Information for Malignant hyperthermia: Definition

  • Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia;Malignant hyperthermia; Fulminating Hyperpyrexia;Hyperthermia of Anesthesia; MH; Malignant Fever; Malignant Hyperpyrexia; Pharmacogenic Myopathy ; Malignant Hyperthermia (MH) is an inherited disorder in which affected individuals do not react appropriately to certain general anesthetia drugs such as halothane, cyclopropane, and the muscle relaxant succinylcholine; This disorder is charactericized by the development of a sudden and rapid high fever, muscle rigidity, and an irregular heartbeat (cardiac arrhythmia), after the administration of general anesthesia or certain muscle relaxants; Malignant Hyperthermia is inherited as an autosomal dominant trait;Once a person is diagnosed with Malignant Hyperthermia, their relatives should be tested to determine if they also have the disorder; [NORD]------------------------------------------------------------------.

    malignant hyperthermia syndrome is an adverse reaction to dopamine-blocking neuroleptics characterized by hyperthermia, muscular rigidity, autonomic dysfunction, and altered consciousness; Malignant hyperthermia; Neuroleptic malignant syndrome; 1/2% to 1% of patients receiving neuroleptics; More than two thirds of patients are male; Young and middle-aged adults; peak 42 yr; Malignant hyperthermia is the familial variant/disorder of neuroleptic syndrome; Differential DX: Heat stroke; Catatonia; Similar syndrome: possible complication of anesthesia, thyroid storm, toxins; Need a Careful drug history; Elevated CPK; Urinary myoglobin; Leukocytosis; Electrolytes; Renal function ; Blood gases; Drug levels;Clinical: "Lead pipe" rigidity; Hyperthermia (38-6° to 42-3° C); Profuse sweating; Tachycardia;Labile BP; Semicomatose; ETIOLOGY: History of haloperidol use in 65% of cases; History of combination drug therapy in 34% of cases; Rare cases after withdrawal of dopamine agonists