Disease Information for Lipoid nephrosis/Minimal change disease: Definition

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  • Glomerular disease causing heavy proteinuria characterized by absence of obvious histologic glomerular changes on light microscopy; It is also called minimal change glomerular disease and minimal lesion glomerulonephritis or

    idiopathic nephrotic disease of childhhod;----------------------------Diagnosis:Urine protein excretion > 3-5 g/1-73 m2 per 24 hours; Hypoalbuminemia (albumin < 3 g/dL); Peripheral edema; In adults, about one-third of patients with nephrotic syndrome have a systemic renal disease such as diabetes mellitus, amyloidosis, or systemic lupus erythematosus; With the current epidemic of type 2 diabetes mellitus, this proportion is slowly increasing; The remainder have idiopathic nephrotic syndrome; The four most common are minimal change disease, focal glomerular sclerosis, membranous nephropathy, and membranoproliferative glomerulonephritis;Clinical Findings; Symptoms and Signs; Peripheral edema is a hallmark of the nephrotic syndrome, occurring when the serum albumin concentration is less than 3 g/dL Edema is most likely due to sodium retention (from renal disease) rather than arterial underfilling from low plasma oncotic pressure; Initially this presents in the dependent areas of the body such as the lower extremities; however, such edema can become generalized; Patients can experience dyspnea due to pulmonary edema, pleural effusions, and diaphragmatic compromise with ascites; Complaints of abdominal fullness may also be present in patients with ascites; Patients may show symptoms and signs of infection more frequently than the general population owing to loss of immunoglobulins and certain complement moieties in the urine; Urinalysis: Proteinuria occurs as a result of an alteration of the negative charge in the GBM;

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