Disease Information for Hyperthyroidism (Graves disease): Definition

  • Hyperactive thyroid disease; most all effects are from excess release of T3 and T4; some enlargement of thyroid and TSH effects are involved; usual cause is autoimmune anti-tsh receptor antibody that triggers receptor; most

    acute problems are from catecholamine release; often recurrent relapsing remitting; may also be caused by hot nodule adenoma or Hashimoto variant disease-----------

    Basedow"s syndrome or disease; Begbie"s disease; Graves" disease; Flajani"s disease; Flajani-Basedow syndrome;

    Marsh"s disease; Parry"s disease; Diffuse toxic goiter, exophthalmic goiter, hyperthyroidism, struma exophthalmica, thyrotoxicosis; A disorder characterized by a triad of hyperthyroidism, goiter, and exophthalmos (bulging eyeballs); The symptoms include cardiac arrhythmias, increased pulse rate, weight loss in the presence of increased appetite, intolerance to heat, elevated basal metabolism rate, profuse sweating, apprehension, weakness, elevated protein-bound iodine level, tremor, diarrhoea, vomiting, eyelid retraction, and stare; Goitres are more prevalent in fresh water and lake countries and less so on the seacoast, due to the lack of iodine in fresh water; Etiology unknown, but may be related to malfunction of the immune system; Female dominance, ratio 4: 1; onset in third or fifth decade of life ----------------[NORD 2005]----