Disease Information for Guillain-Barre syndrome: Definition

  • progressive ascending motor neuron paralysis frequently following an enteric or respiratory infection; understood to be from demyelination syndrome peripheral nerves triggered by humoral autoantibodies; usually but not always self limited; can be lethal untreated with respiratory muscle paralysis; Most cases preceded by GI/Viral illness and most of those are campylobacter jejuni [shared myelin-like antigen]----------------------------------

    Guillain Barre Syndrome; Acute Autoimmune Peripheral; Neuropathy; Acute Immune-Mediated Polyneuropathy; Acute Inflammatory Demyelinating Polyneuropathy; Acute Inflammatory Demyelinating Polyradiculoneuropathy

    Acute Inflammatory Neuropathy; Acute Inflammatory Polyneuropathy; GBS; Landry"s Ascending Paralysis

    Landry-Guillain-Barre-Strohl Syndrome;Post-Infective; Polyneuritis; Acute Motor Axonal Neuropathy; Acute Motor Neuropathy with Conduction Block; Acute Motor-Sensory Axonal Neuropathy Chronic Inflammatory Demyelinating Polyneuropathy (CIDP); Miller-Fisher Syndrome; Multifocal Motor Neuropathy; Multifocal Motor Sensory Demyelinating Neuropathy; Guillain-Barré Syndrome (GBS) is a very rare, rapidly progressive disorder that consists of inflammation of the nerves (polyneuritis) and, usually, muscle weakness, often progressing to frank paralysis; Although the precise cause of GBS is unknown, a viral or respiratory infection precedes the onset of the syndrome in about half of the cases; This has led to the theory that GBS may be an autoimmune disease (caused by the body"s own immune system); Damage to the covering of nerve cells (myelin) and nerve axons (the extension of the nerve cell that conducts impulses away from the nerve cell body) results in delayed nerve signal transmission; There is a corresponding weakness in the muscles that are supplied or innervated by the damaged nerves;