Disease Information for Fatty liver of pregnancy, acute: Definition

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  • Acute fatty liver of pregnancy (AFLP) is a syndrome that occurs late in pregnancy and is often associated with jaundice and hepatic failure; The liver is typically small; AFLP is more common when the mother is carrying a male fetus and may be associated with a deficiency of long-chain-3-hydroxy acyl COH dehydrogenase; AFLP usually necessitates termination of pregnancy due to the risk of rapid and fatal deterioration; Preeclampsia or the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP), which may complicate eclampsia, presents in a similar fashion and progresses to severe liver dysfunction, though typically with a normal size liver; Aminotransferase elevations are typically modest in all of these conditions (generally <500); If diagnosed in time, the disease usually resolves with termination of the pregnancy; Recurrence in subsequent pregnancies is rare; Microvesicular fat accumulation also may be seen as a toxic reaction to valproic acid and with excessive doses of tetracycline ; It is a typical finding in Jamaican vomiting sickness, which is caused by hypoglycin A present in unripened ackee fruit; The combination of lactic acidosis and severe liver injury with microvesicular fat has been described as a complication of nucleoside analogue therapy; --------------(Harrisons 2004)-----------

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