Disease Information for Cerebral thrombotic thrombocytopenia: Definition

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  • Thrombotic thrombocytopenia purpura; present.

    Microangiopathic Hemolytic Anemia; Moschowitz Disease;TTP; This is a rare, serious blood disease; Major symptoms may include a severe decrease in the number of blood platelets (thrombocytopenia), abnormal destruction of red blood cells (hemolytic anemia), and disturbances in the nervous system; Kidney dysfunction and fever are also common; The exact cause of thrombotic thrombocytopenic purpura is unknown.[Nord website 2006]

    EMedicine Author: D Symonette,MD, Thrombotic thrombocytopenic purpura (TTP) is a life-threatening multisystem disorder that is considered a true medical emergency; Moschcowitz first described TTP in 1924 when he noted that his 16 year-old patient had anemia; petechiae; microscopic hematuria; and at autopsy, disseminated microvascular thrombi; Since that time, the pathophysiology, etiology, and medical management of TTP has expanded; This life-threatening condition may have positive outcomes if recognized early and if medical intervention is initiated early; Thrombocytopenic purpura is a syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever, and renal dysfunction; With the introduction of plasma exchange, the survival rate has improved from approximately 3% prior to the 1960s to 82%.

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