Disease Information for Buerger's thromboangiitis obliterans: Definition

  • Obliterative ischemic extremity disease with inflammatory changes in medium sized arteries and veins; usually in 20 to 40 year old males who are heavy smokers; delayed sensitivity to tobacco with toxic angiitis is the theory; coronaries are not involved;often HLA-A9,HLA-B5; superficial thrombophlebitis with arterial thrombosis occurs; disease has not been seen in non-smokers----------

    Buerger"s Disease; Inflammatory Occlusive Peripheral Vascular Disease; Occlusive Peripheral Vascular Disease;

    TAO; Thromboangiitis Obliterans; Buerger"s disease is a very rare disorder that, in most cases, affects young or middle-aged male cigarette smokers; It is characterized by narrowing or blockage of the veins and arteries of the extremities, resulting in reduced blood flow to these areas; The legs are affected more often than the arms; In most cases, the first symptom is extreme pain of the lower arms and legs while at rest; Affected individuals may also experience cramping in the legs when they walk that, in rare cases, may cause claudication; In addition, affected individuals may have ulcers on the extremities, numbness and tingling and a lack of normal blood flow to the fingers and/or toes Raynaud"s Phenomenon, and/or inflammation and clotting of veins (thrombophlebitis); In severe cases, individuals with Buerger"s disease may exhibit tissue death (gangrene) of affected limbs; The exact cause of Buerger"s disease is not known; however, most [all ?] affected individuals are heavy tobacco users.[NORD 2005] ----------------------------------

    Also known as:Endangitis obliterans von Winiwarter-Buerger;

    Winiwarter-Buerger syndrome;Winiwarter-Manteuffel-Buerger syndrome; Billroth-von Winiwarter disease;Endarteritis obliterans, presenile gangrene, thrombangitis obliterans;

    A chronic inflammatory disease of the peripheral vessels, chiefly of the radial and ulnar arteries, sometimes also involving the arteries of the lower limbs, forming blood clots that results in reduced blood flow, possible ulceration, and gangrene; Severe pain of extremities at rest (first symptom in four-fifths of cases), resembling that of intermittent claudication, which usually causes insomnia; Other features include cold sensation at extremities, cold hypersensibility, sudden sweating, dyshidrosis, occasionally, Raynaud’s phenomenon; Central nervous system involvement may include focal lesions of the cerebral cortex with resulting paralysis, sensory disorders, convulsions, aphasia, hemianopsia, personality changes, and mental deterioration; It occurs almost exclusively in males (75 : 1), with a propensity for people of Jewish descent; Larger incidence among cigarette-smoking men between 28 and 50 years of age

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