Disease Information for Botulism: Definition

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  • intoxication due to ingestion of Clostridium botulinum toxin in improperly canned or preserved food, or by other means of ingestion;---------------------------------------------Botulism is causes decreased release of acetylcholine from presynaptic terminals; Toxin produced by Clostridium botulinum spores irreversibly binds to the terminal cholinergic nerve twigs; The result is profound weakness, sometimes with respiratory compromise, shortly after eating contaminated food; A mild decremental response to repetitive nerve stimulation occurs, but a pronounced incremental response occurs after exercise or with rapid (20-Hz) repetitive nerve stimulation-----[Adapted Family Practice Notebook 2004]-------------

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