Disease Information for Adrenogenital syndrome: Definition

Adrenal Hyperplasia, Congenital (General)Synonyms and variants:Adrenal Virilism; Adrenogenital Syndrome; CAH

Corticosterone Methloxidase Deficiency Type I ; Hydroxylase Deficiency.

Subdivisions subsets:11-Beta Hydroxylase Deficiency; 17 Alpha Hydroxylase Deficiency with 17, 20-Lyase Deficiency;

17-Beta Hydroxysteroid Deficiency;17-Beta-HSD Deficiency ;

17-Ketosteroid Reductase Deficiency;21-Hydroxylation Deficiency;3-Beta Hydroxysteroid Dehydrogenase Deficiency ;

3-Beta-HSD 17-Hydroxylation Deficiency ;Cholesterol Desmolase Deficiency; Corticosterone Methyloxidase Deficiency Type II ; Lipoid Hyperplasia-Male Pseudohermaphroditism; Pregnenolone Deficiency.

Discussion: Congenital Adrenal Hyperplasia (CAH) refers to a group of disorders that result from the impaired ability of the adrenal glands to produce vital steroid hormones (corticosteroids), two of which, glucocorticoids and mineralocorticoids, are normally active in the body. Low blood levels of the hormones cortisol, and aldosterone, charge the pituitary gland to produce abnormally high amounts of ACTH (adrenocorticotrophic hormone) which, in turn, stimulates the adrenal cortex to produce androgens or male steroid hormones. Fundamentally, CAH is due to genetic defects (mutations) in the genes controlling the manufacture of the enzymes necessary to produce the hormones of the adrenal cortex.

The various forms of CAH represent enzyme deficiencies at different stages of the production of the steroid hormones. These include 3-Beta Hydroxy-Steroid Dehydrogenase (HSD) Deficiency, 17-Hydroxylase Deficiency, 21-Hydroxylase Deficiency, 17-20 Desmolase Deficiency, 11-Beta Hydroxylase Deficiency, and 17-Alpha Hydroxylase. Almost 95% of cases of CAH are the result of 21-hydroxylase deficiency. The overproduction of male steroid hormones (androgens) at the same time as cortisol and aldosterone are underproduced characterizes the difference between Addison’s disease and CAH. One rare form of CAH can result from the overgrowth of fatty-like cells in the adrenal glands (congenital lipoid hyperplasia). This is also known as male pseudohermaphroditism or 20-22 Desmolase Deficiency.[NORD 2005]

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