Disease Information for Danazol (Danocrine) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Acne flare
Hirsutism
Hypertrichosis
Male escutcheon/pubic hair pattern/female
Male body habitus/female
Male secondary sex characterics/female
Virilism
Morning sickness
Amenorrhea
Amenorrhea, secondary
Demographics & Risk Factors
Established Disease Population
Patient/Endometriosis
Laboratory Tests
Abnormal Lab Findings - Decreased
Thyroid Binding Globulin (Lab)
Abnormal Lab Findings - Increased
Glucagon (Lab)
Diagnostic Test Results
Other Tests & Procedures
Lumbar puncture/Increased CSF pressure/LP test
Associated Diseases & Rule outs
Associated Disease & Complications
Acne vulgaris (acne)
Hyperandrogenism Female
Pancreatitis, acute
Porphyria, attack, acute intermittant
Pseudotumor cerebri
Disease Mechanism & Classification
Drugs
DRUG/Androgens (ex)
DRUG/Hormonal agent/derivative medication (example)
DRUG/Pituitary gonadotropin release prevented
DRUG/Teratogenic potential/effect (D plus )
Pathophysiology
Pathophysiology/Androgen Excess Female
Pathophysiology/CSF Pressure Increased
Pathophysiology/Hyperandrogenic chronic anovulation
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
(17Alpha) pregna 2,4 dien 20 yno(2,3 d) isoxazol 17 ol, (17alpha) Pregna 2,4 dien 20 yno(2,3 d)isoxazol 17 ol, 1 Ethynyl 2,3,3a,3b,4,5,10,10a,10b,11,12,12a dodecahydro 10a,12a dimethyl 1H cyclopental(7,8)phenanthro(3,2 d)isoxazol 1 ol, 17Alpha ethynyl 17beta hydroxy 4 androsteno(2,3 d)isoxazole, DAN, Danazol, Danazol (substance), DANAZOL PREPARATION, Danazol preparation (product), Danazol preparation (substance), Danazol product, Pregna 2,4 dien 20 yno(2,3 d)isoxazol 17 ol (17alpha), Brand name/Danocrine (Danazol)
Treatment
Drug Therapy - Contraindication
RX/Warfarin (Coumadin)
Drug Dosage
DRUG/.$$$$ Very Expensive
DRUG/.$$$$$ Most Expensive
DRUG/Dose 100 mgm (Unit/Pill/Capsule size)
DRUG/Dose 200 mgms (Unit/Pill/Capsule size)
DRUG/Dose 50 mgm (Unit/Pill/Capsule size)
DRUG/Generic available
DRUG/Oral medication (ex)
Definition

Androgenic synthetic drug; used in endometriosis; less used because of masculinizing side effect; stops menses by preventing gonadotropin release

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External Links Related to Danazol (Danocrine) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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