Disease Information for Dacarbazine (DTIC) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Rash
Associated Diseases & Rule outs
Associated Disease & Complications
Drug induced Photosensitivity rash
Drug rash/Drug induced rash
Fetal anomaly
Hepatic vein thrombosis (Budd-Chiari)
Photosensitivity dermatitis
Phototoxicity
Disease Mechanism & Classification
Drugs
DRUG/ABVD ChemoRX protocol (comb)
DRUG/Alkylating agents (example)
DRUG/Chemotherapeutics/cancer drugs/etc (category)
DRUG/Cytotoxic/chemotherapy medication (example)
DRUG/Teratogenic potential/effect (D plus )
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
1H imidazole 4 carboxamide 5 (3,3 dimethyl 1 triazenyl), 4 (Dimethyltriazeno)imidazole 5 carboxamide, 5 (3 3 dimethyl 1 triazenyl) 1H imidazole 4 carboxamide, 5 (3,3 Dimethyl 1 triazeno)imidazole 4 carboxamide, 5 (dimethyltriazeno)imidazole 4 carboxamide, 5(or 4) (dimethyltriazeno)imidazole 4(or 5) carboxamide, Carboxamide Dimethyl Imidazole, Dacarbazina, Dacarbazine, Dacarbazine DTIC, Dacarbazine (product), Dacarbazine (substance), DACARBAZINE PREPARATION, Dakarbazin, Decarbazine, DIC, DIC Dacarbazine, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Imidazole Carboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, Dimethyl triazeno imidazole carboximide, dimethyltriazenoimidazole carboxamide, DTIC, DTIC Dacarbazine, ICDT, Imidazole Carboxamide Dimethyl, Imidazole Carboxamide Dimethyltriazeno, Brand name/Carboximide (Dacarbazine), Brand name/DTIC-Dome (Dacarbazine), Synonym/Imidazole (Dacarbazine)
Definition

Primarily an Antineoplastic cancer chemotherapy drug; Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell division; Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often

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External Links Related to Dacarbazine (DTIC) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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