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Disease Information for Dacarbazine (DTIC) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Rash

Associated Diseases & Rule outs

Associated Disease & Complications

Drug induced Photosensitivity rash

Drug rash/Drug induced rash

Fetal anomaly

Hepatic vein thrombosis (Budd-Chiari)

Photosensitivity dermatitis

Phototoxicity

Disease Mechanism & Classification

Drugs

DRUG/ABVD ChemoRX protocol (comb)

DRUG/Alkylating agents (example)

DRUG/Chemotherapeutics/cancer drugs/etc (category)

DRUG/Cytotoxic/chemotherapy medication (example)

DRUG/Teratogenic potential/effect (D plus )

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

1H imidazole 4 carboxamide 5 (3,3 dimethyl 1 triazenyl), 4 (Dimethyltriazeno)imidazole 5 carboxamide, 5 (3 3 dimethyl 1 triazenyl) 1H imidazole 4 carboxamide, 5 (3,3 Dimethyl 1 triazeno)imidazole 4 carboxamide, 5 (dimethyltriazeno)imidazole 4 carboxamide, 5(or 4) (dimethyltriazeno)imidazole 4(or 5) carboxamide, Carboxamide Dimethyl Imidazole, Dacarbazina, Dacarbazine, Dacarbazine DTIC, Dacarbazine (product), Dacarbazine (substance), DACARBAZINE PREPARATION, Dakarbazin, Decarbazine, DIC, DIC Dacarbazine, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Imidazole Carboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, Dimethyl triazeno imidazole carboximide, dimethyltriazenoimidazole carboxamide, DTIC, DTIC Dacarbazine, ICDT, Imidazole Carboxamide Dimethyl, Imidazole Carboxamide Dimethyltriazeno, Brand name/Carboximide (Dacarbazine), Brand name/DTIC-Dome (Dacarbazine), Synonym/Imidazole (Dacarbazine)

Definition

Primarily an Antineoplastic cancer chemotherapy drug; Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell division; Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often

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External Links Related to Dacarbazine (DTIC) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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