Disease Information for Cylindroma, Spiegler

Clinical Manifestations
Disease Progression
Course/Chronic disorder
Course/Chronic only
Disease Mechanism & Classification
CLASS/Dermatologic/Subcutaneous (category)
Pathophysiology/Cylindromas (eccrine glands carcinoma)
PROCESS/Neoplastic (category)

"Cylindroma"synonyms:Spiegler"s Tumour;Turban Tumour;

Dermal Eccrine Cylindroma; Tomato Tumour; Ancell-Spiegler Cylindroma; Poncet-Spiegler Tumour; Dermal respiratory tumor eccrine cells in adenoids as cystic adenoid carcinoma, slow growing carcinoma spreads along nerves;

pathology: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells; When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance; Such tumours occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands; They are malignant but slow-growing, and tend to spread locally via the nerves; (Dorland, 27th ed);-----------------------------------------------------------Adenoid Cystic Carcinoma; ACC; Adenocystic Carcinoma; Cribriform Carcinoma; Cylindroma

Adenoid cystic carcinoma (ACC) is a relatively rare form of cancer that most commonly develops in the salivary glands or other regions of the head and neck; In some cases, ACC may arise in other primary sites, such as the skin; the breast; the neck of the uterus (cervix) in females; the prostate gland in males; or other areas; The term "cancer" refers to a group of diseases characterized by abnormal, uncontrolled cellular growth that invades surrounding tissues and may spread (metastasize) to distant bodily tissues or organs via the bloodstream, the lymphatic system, or other means; Different forms of cancer, including adenoid cystic carcinoma, may be classified based upon the cell type involved, the specific nature of the malignancy, the tissues or organs affected, and the disease"s clinical course; ACC tumors are characterized by a distinctive pattern in which abnormal "nests" or cords of certain cells (epithelial cells) surround and/or infiltrate ducts or glandular structures within the affected organ; These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes (hyaline membranes); Such characteristics are apparent during microscopic evaluation of the tumor cells; ACC is considered a low-grade malignancy that has a history of slow growth, but tends to be aggressively invasive and to infiltrate nearby lymph nodes as well as the "sheaths" or coatings surrounding nerve fibers (perineural spaces); This form of cancer may have a tendency to recur later at the site where it first developed (local recurrence) and to spread to distant bodily sites, particularly the lungs, potentially resulting in life-threatening complications

-----------------[NORD 2005]--------------


External Links Related to Cylindroma, Spiegler
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)