Disease Information for Cyclophosphamide (Cytoxan/Neosar) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Baldness/Alopecia
Hair loss
Non-scarring Alopecia/balding
Disease Progression
Pancytopenia with Hypocellular Marrow
Laboratory Tests
Abnormal Lab Findings - Decreased
Neutrophiles (Lab)
Osmolality, serum (Lab)
Sodium, serum (Lab)
Abnormal Lab Findings - Increased
Bilirubin, serum (Lab)
Indirect bilirubin (Lab)
Diagnostic Test Results
Other Tests & Procedures
Skin test anergy
Isotope Scan
Isotope/Gallium 67 lung scan abnormal
Associated Diseases & Rule outs
Associated Disease & Complications
Agranulocytosis
Anemia
Anemia, aplastic
Anergic status
Bilirubinemia
Bladder polyp
Carcinoma, bladder, transitional
Chemical cystitis
Cytoxan/Drug induced Cystitis
Drug induced Anemia.
Drug induced Baldness/Alopecia
Drug induced Cardiomyopathy/Cardiotoxicity.
Drug induced Hair loss
Drug induced Hyponatremia
Drug induced Inappropriate ADH syndrome/SIADHS
Drug induced Interstitial Lung disease.
Drug induced Lung disease.
Drug induced Neutropenia.
Drug induced Pulmonary fibrosis.
Fetal anomaly
Granulocytopenia/Neutropenia
Hemorrhagic cystitis
Hyponatremia
Hypo-Osmolar State
Inappropriate ADH secretion syndrome
Interstitial lung involvement/manifestation
Myocarditis, toxic
Pancytopenia
Pulmonary fibrosis
SIADH, idiopathic
Hematuria
Disease Mechanism & Classification
Drugs
DRUG/ACE protocol drug combination (ex)
DRUG/Alkylating agents (example)
DRUG/Anti-rheumatoid arthritis drug (example)
DRUG/Chemotherapeutics/cancer drugs/etc (category)
DRUG/CHOP ChemoRx Protocol (Comb)
DRUG/COPE ChemoRX protocol (comb)
DRUG/H-CAP protocol (four drugs) (comb)
DRUG/Late leukemia/lymphoma complication
DRUG/Nitrogen mustard alkylating agent
DRUG/Oral Anti-cancer drug (ex)
DRUG/Prevents transplant/allograft rejection
DRUG/Teratogenic potential/effect (D plus )
DRUG/Teratogenic/OBGYN Class X/Pregnancy DANGER
DRUG-Liver metabolism/bile excretion
Pathophysiology
Pathophysiology/Interstitial lung disorder (ex).
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
( ) Cyclophosphamide, 2H 1,3,2 Oxazaphosphorin 2 amine N,N bis(2 chloroethyl)tetrahydro 2 oxide, 2H 1,3,2 oxazaphosphorin 2 amine N,N is(2 chloroethyl)tetrahydro ,2 oxide, admin, Ciclofosfamida, Ciclofosfamide, Claphene, CPM, CTX, Cyclophospham, Cyclophosphamide, Cyclophosphamide (product), Cyclophosphamide (substance), CYCLOPHOSPHAMIDE PREPARATION, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, CYT, Cytophosphan, Cytophosphane, Mitoxan, N,N Bis(2 chloroethyl)tetrahydro 2H 1,3,2 oxazaphosphorin 2 amine 2 Oxide, Syklofosfamid, Zytoxan, Brand name/Cytoxan (Cyclophosphamide), Brand name/Endoxan (Cyclophosphamide), Brand name/Neosar (Cyclophosphamide)
Treatment
Drug Therapy - Indication
RX/Ciclosporine Cyclosporin (Sandimmune)
RX/Low-dose aspirin
Drug Dosage
DRUG/.$$$$$ Most Expensive
DRUG/.1990 or before
DRUG/Dose Unit dose Vial preparation
DRUG/Oral medication (ex)
Definition

Primarily an Antineoplastic cancer chemotherapy drug. Alkylating agents interferes with methylation of DNA in mitosis, inhibits cell division. Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often. Used in a wide range of

auto-immune disorders.

(Edit)

External Links Related to Cyclophosphamide (Cytoxan/Neosar) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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