Disease Information for Cyclobenzaprine (Flexeril) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Dizzy on Standing/Giddy Response
Orthostatic drop in blood pressure
Tachycardia/Fast heart rate
Decreased sweating/Absent sweating
Muscle fasciculations
Muscle twitches
Apathy/Indifference
Confusion/Disoriented
Delirium
Delirium/Agitated delirium
Lethargy/torpor
Slow speech
Slurred speech
Slurred Speech/Acute
Slurred speech/Chronic
Staggering Gait
Unable to tandem walk/straight line
Unconscious/Narcosis status
Manic behavior
Listlessness/lassitude
Mydriasis/wide pupils
Associated Diseases & Rule outs
Associated Disease & Complications
Acute respiratory failure/Respiratory arrest
Anhydrosis/Absent sweating/diffuse
Anticholinergic/belladonna group toxidrome
Coma/Unconscious
Orthostatic syncope Hypotension
Ataxia Disorder
Disease Synergy - Causes
Synergy/Age
Disease Mechanism & Classification
Drugs
DRUG/Chronic pain/Neuropathic pain adjunct medication
DRUG/Muscle relaxant medication (example)
DRUG/Safe in pregnancy patient (B)
Pathophysiology
Pathophysiology/CNS depression
Pathophysiology/Tissue hypoxia/potential
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Causes Hyperthermia/Fever
TOXIN/Brain death/mimic
Synonyms
Synonym
admin, Cyclobenzaprine (Flexeril), Brand name/Amrix (Cyclobenzaprine) ER, Brand name/Fexmid (Cyclobenzaprine), Brand name/Flexeril (Cyclobenzaprine)
Treatment
Drug Therapy - Indication
RX/Physostigmine
Drug Dosage
DRUG/.1990 or before
DRUG/Dose 10 mgm (Unit/Pill/Capsule size)
DRUG/Dose TID Medication
DRUG/Generic available
DRUG/Half-life 24-72 hours
DRUG/Half-life very long (days)
DRUG/Oral medication (ex)
Definition

a central muscle relaxant drug with some tricyclic antidepressant effect; derivative of TCA drugs; watch for urinary retention and anticholinergic effects

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External Links Related to Cyclobenzaprine (Flexeril) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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