Disease Information for Cyclic neutropenia syndrome

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Clinical Manifestations
Signs & Symptoms
Buccal ulcers
Oral lesion/ulcer
Oral mucosa erythematous lesions
Oral Ulcers in Children
Tongue Ulcer
Ulcerative stomatitis
Cervical adenopathy
Recurrent URI/Colds/LRI infections
Arthralgias Polyarthralgias
Joint Pains
Joint pains Arthralgias in Children
Constitutional symptoms
Cyclic Periodic Recurrent Fevers
Fever
Fever Febrile Possible
Fever in kids
Fevers, low grade/recurrent
Flu-Like Syndrome
High body temperature
Periodic fever
Clinical Presentation & Variations
Presentation/Recurrent Infections
Presentation/Recurrent respiratory infections
Presentation/Recurrent Bronchitis LRI
Presentation/Recurrent Sinusitis
Presentation/Resistant Sinusitis Poor control
Disease Progression
Course/Benign course/disorder
Course/Chronic disorder
Course/Chronic only
Course/Monthly cycle/periodicity
Course/Periodic disease/21 day cycle
Course/Periodic Episodic
Course/Relapsing
Course/Relapse Cycles 3-6 weeks
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Child
Population/Children/all
Population/Male
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Abnormal Lab Findings - Decreased
WBC
Band forms (Lab)
Monocytes (Lab)
Neutrophiles (Lab)
Platelet count (Lab)
Reticulocytes (Lab)
WBC/White Blood Cell Count/Leukocytes (Lab)
Diagnostic Test Results
Pathology
Bone Marrow/Maturation arrest/granulocytes
Associated Diseases & Rule outs
Associated Disease & Complications
Abscess, perianal/pararectal
Aphthous stomatitis Aphthous oral lesions
Bacterial infection, general
Cyclic neutropenia
Gingivitis
Granulocytopenia/Neutropenia
Infections
Periodontitis/periodontal disease
Stomatitis
Disease Mechanism & Classification
Class
CLASS/Hematologic (category)
CLASS/Leukocyte involvement/disorder (ex)
CLASS/Gum/gingival involvement/disorder (ex)
Pathophysiology
Pathophysiology/Gene locus 19p13
Pathophysiology/Gene locus chromosome 19
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Hereditary disease/Adult manifestations
Pathophysiology/ELA2 (Neutrophile Elastase) Gene Mutation
Pathophysiology/Gene locus Male Chromosome Y
Pathophysiology/Lack of GM-CSF
Pathophysiology/Maternal Chromosome mutation
Pathophysiology/Varied Hereditary Pattern
Pathophysiology/Chemotaxis failure/phagocytes/effect
Pathophysiology/Gene locus 19p13.3
Process
PROCESS/Autosomal dominant hereditary disease (ex).
PROCESS/Congenital/developmental (category)
PROCESS/Genetic disorder/Spontaneous mutations/sporadic
PROCESS/Hereditary/Genetic predisposition (ex)
PROCESS/Hereditofamilial (category)
Synonyms
Synonym
Synonym
AGRANULOCYTOSIS CYCLIC, Cyclic Agranulocytosis, Cyclic haematopoiesis, Cyclic hematopoiesis, Cyclic Neutropenia, Cyclic neutropenia (disorder), Cyclical neutropaenia, Cyclical neutropenia, Cyclical neutropenia (disorder), Dysplasia Myelocytic Periodic, LEUKOPENIA CYCLIC, NEUTROPENIA CYCLIC, PERIODIC NEUTROPENIA, Synonym/Periodic neutropenia, Synonym/Cyclic agranulocytosis, Synonym/Cyclic Hematopoesis, Synonym/Cyclic leukopenia, Synonym/Dysplasia, myelocytic periodic, Synonym/Periodic neutropenia
Treatment
Drug Therapy - Indication
RX/GM-CSF(Granulocyte-macrophage colony stimulating)
SX/Stem cell transplant/allogenic
SX/Stem-cell transplant
Definition

Neutropenia, Cyclic; CN; Cyclic Hematopoiesis; Human Cyclic Neutropenia ; Periodic Neutropenia; Cyclic neutropenia is a rare blood disorder characterized by recurrent episodes of abnormally low levels of certain white blood cells (neutrophils) in the body; Neutrophils are instrumental in fighting off infection by surrounding and destroying bacteria that enter the body; Symptoms associated with cyclic neutropenia may include fever, a general feeling of ill health (malaise), and/or sores (ulcers) of the mucous membranes of the mouth; In most cases, individuals with low levels of neutrophils (neutropenia) are abnormally susceptible to recurrent infections----[NORD]-----------

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External Links Related to Cyclic neutropenia syndrome
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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