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Disease Information for Cyanide CBW (Cyanogen chloride) exposure
- Clinical Manifestations
- Signs & Symptoms
- Cyanosis
- Loss of bowel control/incontinence acute
- Paresthesias
- Seizures
- Bloodshot eyes/Conjunctival injection
- Red Eyes Bilateral
- Scleral Injection
- Clinical Presentation & Variations
- Presentation/Collapse Seizure Acidosis Anaerobic
- Disease Progression
- Course/Acute
- Course/Acute only
- Demographics & Risk Factors
- Exposure Factors
- Exposure/Terrorist Chemical weapon agent
- Exposure/Terrorist/Chemical-biological weapon (CBW)
- Occupational Factors
- Occupation/Soldier/officer military
- Event, Activity, Behavioral & Seasonal Factors
- Event/Mass exposure/community illness/death
- Laboratory Tests
- Abnormal Lab Findings - Decreased
- PCO2, arterial blood (Lab)
- pH, arterial blood (Lab)
- Abnormal Lab Findings - Increased
- Anion gap (Lab)
- Lactic acid/Lactate (Lab)
- RBC Cyanide levels
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Acidosis
- Acidosis, metabolic
- Asphyxia/suffocation
- Chemical Tracheobronchitis
- Convulsions (grand mal)
- Hypochloremic metabolic alkalosis
- Lactic acidosis
- Laryngeal edema
- Metabolic Acidosis with High Anion Gap
- Tracheal edema
- Disease Mechanism & Classification
- Process
- PROCESS/Poison/specific (category)
- Toxin
- TOXIN/Aerosolized Terror/Weapon chemical
- TOXIN/CBRNE (Chemical/Biologic Weapons All) potential
- TOXIN/Chemical Weapon/Terrorist/Military
- TOXIN/Fruity odor/bitter almonds odor
- TOXIN/Increases Respiratory Rate
- TOXIN/Poison/Inorganic (category)
- TOXIN/Weapon/anti-personnel agent/poison (ex)
- Treatment
- Drug Therapy - Indication
- RX/Hydroxocobalamine injection
- Definition
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Cyanide poisoning by aerosol gaseous state , HCN, or cyanogen chloride as CBW terror attack or military exposure;
While liquid cyanide can be absorbed through the skin or eyes, the primary route of exposure is by inhalation or ingestion; Following absorption, cyanide is distributed rapidly to all organs and tissues in the body; Cyanide combines with ferric iron in cytochrome a3 (a component of the cytochrome oxidase complex in mitochondria) and inhibits this enzyme; This prevents intracellular oxygen use and results in imbalance between ATP hydrolysis and production; Metabolic acidosis is a hallmark of cyanide toxicity; It develops as cells are forced to use anaerobic metabolism and accumulate hydrogen ions and lactate; clinically seizures followed by respiratory arrest then
circulatory collapse; color good by global hypoxia effects
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- External Links Related to Cyanide CBW (Cyanogen chloride) exposure
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)