Disease Information for Curare Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Cyanosis
Low Blood Pressure
Slow pulse/Bradycardia
Dysphagia Swallowing Difficulties
Acute Motor Weakness
Flaccid jaw
Muscle tone/decreased
Muscle weakness
Prolonged Effect NM Blocking Agents
Abdominal reflex decreased
Absent deep tendon reflexes
Absent knee reflexes
Areflexia
Dysarthria
Flaccid muscle paralysis
Level of alertness maintained
Paralysis
Apnea In Children
Apnea In Infants/Newborn
Dyspnea
Hypoventilation Signs
Respiratory excursions decreased
Shallow breathing
Shortness of breath/SOB
Difficulty Talking
Weakness
Clinical Presentation & Variations
Presentation/Intentional poisoning Healthy person
Laboratory Tests
Abnormal Lab Findings - Decreased
pO2, arterial blood (Lab)
Abnormal Lab Findings - Increased
Carbon Dioxide Total Content/CO2
PCO2, arterial blood (Lab)
Diagnostic Test Results
Electrodiagnosis
Pulse oximetry/low O2 saturation
X-RAY With contrast
UGI/Esophagus motility disorder
Associated Diseases & Rule outs
Rule Outs
Botulism
Eaton-Lambert syndrome
Associated Disease & Complications
Acidosis, respiratory
Acute respiratory failure/Respiratory arrest
Apnea
Curariform drug toxicity
Hypercapnea Hypercarbia
Hypotension
Hypoventilation, alveolar
Hypoxemia
Hypoxia, systemic
Myasthenic crisis
Paralytic Disorder
Respiratory muscle paralysis
Respiratory muscle weakness
Urticaria/hives
General paralysis/General Paresis
Disease Mechanism & Classification
Drugs
DRUG/Narrow range of safety (effect/toxic)
DRUG/Neuromuscular blocker medication (example)
Pathophysiology
Pathophysiology/Lung Hypoventilation
Pathophysiology/Lung Ventilation Neuromuscular
Pathophysiology/Tissue hypoxia/potential
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Inactivated orally/Injection danger
TOXIN/Intentional/classical/regional poison
TOXIN/Neurotoxin effect
TOXIN/Onset Immediate/Minutes
TOXIN/Used as an Arrow poison
TOXIN/Alert patient/lethal course/Aware
TOXIN/Brain death/mimic
Treatment
Drug Dosage
DRUG/Orally ineffective drug
Definition

Neuromuscular paralytic drug; anesthesia use; parenteral preparations; little used

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External Links Related to Curare Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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