Disease Information for Cryoglobulinemia

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Clinical Manifestations
Signs & Symptoms
Necrosis/nose tip/extremities signs
Regional pallor/vasospasm
Vasospasm of extremities/Signs
White/blanching area discoloration
Cold exposed areas/purpuric lesions
Cold urticaria
Fever and Rash
Necrotizing lesions/cold exposed areas
Purpura
Rash
Rash on extremities
Rash on legs/ankles
Rash triggered by cold exposure
Tender nodules
Painful finger pads
Painful/finger tips
Hypesthesia
Numbness/hands
Arthralgias Polyarthralgias
Joint Pains
Joint pains Arthralgias in Children
Cold intolerance
Fever
Flu-Like Syndrome
High body temperature
Clinical Presentation & Variations
Pulmonary Renal Syndromes
Nephritis Syndrome Low Complement
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Established Disease Population
Patient/Hepatitis C
Population Group
Child
Population/Pediatrics population
Event, Activity, Behavioral & Seasonal Factors
Event/Wintertime
Sex & Age Groups
Population/Child
Population/Child-Infant Only
Population/Children/all
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Complement C4 very low/C3 Slight Decrease
Rouleaux RBC pattern/blood smear (Lab)
Abnormal Lab Findings - Decreased
Complement (total CH50) level (Lab)
Abnormal Lab Findings - Increased
Cryoglobulins (Lab)
Gamma globulin (Lab)
Globulin, serum (Lab)
IGG/Immunoglobulin G (Lab)
IGM/Immunoglobulin M (Lab)
Lactic Dehydrogenase (LDH LH) (Lab)
Rheumatoid factor (Lab)
Rouleaux formation (Lab)
Sed Rate/ESR/Sedimentation rate (Lab)
URINE Bence Jones protein
URINE Protein (Albumin)
Diagnostic Test Results
Pathology
BX/Skin biopsy/Leukoclastic vasculitis
Associated Diseases & Rule outs
Rule Outs
Adult Still's disease/RA presentation
Paroxysmal cold hemoglobinuria
Polyarteritis nodosa
Vasculitis syndrome
Associated Disease & Complications
Acute Tubulointerstitial Nephropathy
Cryoglobulinema
Cutaneous vasculitis
Glomerulonephritis, rapidly progressive
Glomerulonephritis,membranoproliferative
Glomerulonephritis/Glomerulitis
Hyperglobulinemia
Hyperviscosity syndrome
Livedo reticularis
Nephritis tubulointerstitial
Peripheral neuropathy
Polyarteritis nodosa
Polyneuritis
Proteinuria
Raynaud's syndrome
Rheumatoid arthritis
Hypersensitivity/Leukoclastic Vasculitis
Leg ulcers
Polyneuropathy
Proteinuria in Children
Disease Mechanism & Classification
Class
CLASS/Vascular Small Vessel Disorder
Pathophysiology
Pathophysiology/Polyclonal IGM/cold-reacting
Pathophysiology/Hypersensitivity Vasculitis
Pathophysiology/Leukoclastic Vasculitis
Pathophysiology/Peripheral hemostasis
Pathophysiology/Small Vessel Vasculitis
Pathophysiology/Dysproteinemia (Ex)
Pathophysiology/Proteins/blood disorder (ex)
Pathophysiology/Complement C4 Consumption
Pathophysiology/Complement/immune complex event
Pathophysiology/Immune complex disease
Process
PROCESS/Biochemical (category)
PROCESS/Metabolic/storage disorder (category)
PROCESS/Paraproteinemias (ex)
Treatment
Drug Therapy - Indication
RX/Interferon alpha
RX/Rituximab (Rituxan)
Other Treatments
TX/Plasmapheresis/exchange.
TX/Treat underlying cause
Definition

A condition characterized by the presence of abnormal or abnormal quantities of cryoglobulins in the blood. They are precipitated into the microvasculature on exposure to cold and cause restricted blood flow in exposed areas.

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External Links Related to Cryoglobulinemia
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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