Disease Information for Cross syndrome

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Clinical Manifestations
Signs & Symptoms
Athetosis
Choreoathetoid movement
Equinus Posture/Ankles
Spasticity/Spastic gait
Narrow Palpebral Fissures
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Child
Population/Child-Infant Only
Population/Children/all
Associated Diseases & Rule outs
Associated Disease & Complications
Albinism
Cross syndrome
Gingival hyperplasia
Microphthalmos
Disease Mechanism & Classification
Pathophysiology
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Process
PROCESS/Eponymic (category)
PROCESS/Hereditofamilial (category)
PROCESS/INCIDENCE/Esoteric disease (example)
PROCESS/Albinism disorders (ex).
Definition

A syndrome of gingival fibromatosis, pigmentation disorders, microphthalmia, and delayed psychomotor development; It was first observed in the Kramer family, hence the synonym Kramer syndrome;------------------------------------Oculocerebral Syndrome with Hypopigmentation;

Cross Syndrome; Cross-McKusick-Breen Syndrome;

Depigmentation-Gingival Fibromatosis-Microphthalmia;

Kramer Syndrome; Oculocerebral Syndrome with Hypopigmentation is an extremely rare inherited disorder characterized by the lack of color (hypopigmentation) of the skin and hair and abnormalities of the central nervous system that affect the eyes and certain parts of the brain (oculocerebral); Physical findings at birth include unusually light skin color and silvery-gray hair; Abnormal findings associated with the central nervous system may include abnormal smallness of one or both eyes (microphthalmia); clouding (opacities) of the front, clear portion of the eye through which light passes (cornea); and/or rapid, involuntary eye movements (nystagmus); Additional symptoms that may develop during infancy include involuntary muscle contractions, associated loss of muscle function (spastic paraplegia), developmental delays, and/or mental retardation; Oculocerebral Syndrome with Hypopigmentation is believed to be inherited as an autosomal recessive genetic trait---------[NORD]----------

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NEJM (The New England Journal of Medicine)
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