Disease Information for Crohns disease (Regional enteritis)
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bowel regional enteritis, Cicatrizing enterocolitis, CROHN DISEASE, Crohn's... (more)
Crohn's disease is a chronic inflammatory disease of the intestines; It primarily causes ulcerations (breaks in the lining) of the small and large intestines, but can affect the digestive system anywhere from the mouth to the anus; It also is called granulomatous enteritis or colitis, regional enteritis, ileitis, or terminal ileitis;
Crohn's disease is related closely to another chronic inflammatory condition that involves only the colon called ulcerative colitis; Together, Crohn's disease and ulcerative colitis are frequently referred to as inflammatory bowel disease (IBD); Men and women are equally affected; IBD most commonly begins during adolescence and early adulthood, but it also can begin during childhood and later in life; Crohn's disease tends to be more common in relatives of patients with Crohn's disease; It also is more common among relatives of patients with ulcerative colitis;
The cause of Crohn's disease is unknown; Some scientists suspect that infection by certain bacteria, such as strains of mycobacterium, may be the cause of Crohn's disease; To date, however, there has been no convincing evidence that the disease is caused by infection; Crohn's disease is not contagious; Although diet may affect the symptoms in patients with Crohn's disease, it is unlikely that diet is responsible for the disease; In the early stages, Crohn's disease causes small, scattered, shallow, crater-like areas (erosions) on the inner surface of the bowel; These erosions are called aphthous ulcers; With time, the erosions become deeper and larger, ultimately becoming true ulcers (which are deeper than erosions) and causing scarring and stiffness of the bowel; As the disease progresses, the bowel becomes increasingly narrowed, and ultimately can become obstructed; Deep ulcers can puncture holes in the wall of the bowel, and bacteria from within the bowel can spread to infect adjacent organs and the surrounding abdominal cavity;
When Crohn's disease narrows the small intestine to the point of obstruction, the flow of the contents through the intestine ceases; Sometimes, the obstruction can be caused suddenly by poorly-digestible fruit or vegetables that plug the already-narrowed segment of the intestine; When the intestine is obstructed, digesting food, fluid and gas from the stomach and the small intestine cannot pass into the colon; The symptoms of small intestinal obstruction then appear, including severe abdominal cramps, nausea, vomiting, and abdominal distention; Obstruction of the small intestine is much more likely since the small intestine is much narrower than the colon to begin with; Deep ulcers can puncture holes in the walls of the small intestine and the colon, and create a tunnel between the intestine and adjacent organs; If the ulcer tunnel reaches an adjacent empty space inside the abdominal cavity, a collection of infected pus (an abdominal abscess) is formed; Patients with abdominal abscesses can develop tender abdominal masses, high fevers, and abdominal pain;
[Medicinenet_com 2007]
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Crohn's disease is a chronic inflammatory disease of the intestines; It pri... (more) (edit)
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Demographics & Risk Factors[next]
- Travel, Geographic & Climate Related Factors
- Ethnic or Racial Factors
- Past History
- Family History
- Sex & Age Groups
- Population/Adolescent
- Population/Adult/all
- Population/Fifties adult
- Population/Forties adult
- Population/Middle-aged adult
- Population/Thirties adult
- Population/Young adult
Clinical Manifestations[previous][top][next]
- Typical Clinical Presentation
- Arthritis Syndrome with Eye Lesions
- Lactose intolerance, acquired/temporary
- Presentation/Adolescent female abdominal pain
- Presentation/Fever with arthritis signs
- Single Joint Arthritis
- Disease Progression
- Course/Chronic disorder
- Onset/in third decade
- Signs & Symptoms
- Adolescent
- Middle Age Adult
- Young Adult
- Clubbing/fingers
- Hyperhidrosis/Chronic sweating excess
- Night sweats
- Sweats/excess perspiration
- Abdominal Mass
- Abdominal Mass in Children
- Abdominal muscle rigidity
- Abdominal Pain
- Abdominal pain after bowel movement
- Abdominal pain after meals/eating food
- Abdominal Pain Crampy
- Abdominal Pain in Adolescent
- Abdominal Pain in Children
- Abdominal tenderness
- Active Bowel Sounds
- Acute abdomen
- Acute abdomen with no signs
- Anorectal pain
- Anorexia/Decreased appetite
- Anus Pain
- Appendicitis pain syndrome
- Blood in stool
- Bloody diarrhea
- Borborygmi/Bowel sound increased
- Bowel habit change
- Bowel/Stool Incontinence
- Chronic Abdominal Pain
- Colicky Abdominal Pain
- Diarrhea
- Diarrhea and Weight Loss
- Diarrhea, chronic
- Diarrhea, crampy
- Diarrhea, nocturnal/movement in night
- Diarrhea, recurrent
- Diffuse Abdominal Pain
- Failure to Thrive
- Glove stool exam guaiac positive
- Hematochezia/Blood per Rectum
- Hyperactive Bowel Sounds
- Indigestion
- Left Lower Quadrant Pain in Children
- Lower Abdominal Mass
- Lower Abdominal Pain
- Mass in RLQ
- McBurneys point tenderness
- Perianal rash
- Perianal/Anal ulcers
- Periumbilical Abdominal Pain
- Periumbilical Pain in Elderly
- Protracted painful diarrhea/complaint
- RAP syndrome/children/Recurrent abdominal pain
- Rectal Blood/Bleeding in Children
- Rectal exam/abnormal
- Rectal pain
- Rectal right-sided tenderness
- Rectal urgency
- Recurrent Abdominal Pain
- Right Lower Quadrant Pain/Tenderness
- Sausage shaped mass/RLQ
- Severe abdominal pain
- Staining underclothes/stool
- Stool color/appearance abnormal
- STOOL Mucus excess
- STOOL Pus/purulence
- Ten bowel movements a day
- Tenesmus
- Thickened bowel loops palpable/Abdomen
- Oral lesion/ulcer
- Adnexal mass
- Dysmenorrhea
- Pelvic pain
- Pelvic pain/chronic
- Arthralgias
- Arthritis and Diarrhea
- Arthritis and weight loss
- Arthritis with Abdominal Pain
- Back Pain
- Backache
- Joint exam/signs
- Joint Pains
- Joint pains/Arthralgias in Elderly
- Low Back Pain
- Monoarticular Arthritis/One joint acute
- Pneumaturia/air (gas) in bladder/signs
- Chills
- Chronically ill patient/signs
- Constitutional symptoms
- Enervated/extreme acute fatigue
- Fatigue/chronic
- Fatigue/tiredness/exhaustion
- Fever
- Fever of unknown origin/chronic fever
- Fever Remittant/Recurrent
- Fever with High sed Rate
- Fever, intermittant/recurrent
- Fever/Febrile Possible
- Fevers, low grade/recurrent
- Flu-Like Syndrome
- Perineum scarring/ulcerating lesions
- Perineum/draining sinus tract
- Short stature
- Short stature/child
- Weight loss
- Typical Clinical Presentation
Laboratory Tests[previous][top][next]
- Microbiology & Serology Findings
- Abnormal Lab Findings (Non Measured)
- Acute inflammatory markers elevated (Lab)
- Card15/NOD2 Gene mutation positive
- Chromosomal/Karyotype analysis abnormality (Lab)
- Macrocytosis/smear (Lab)
- P-ANCA Negative and ASCA Positive status (Lab)
- Hypercalciuria with normal serum calcium
- Hypercalciuria/Normocalcemia pattern
- Fecal Calprotectin Abnormal
- Fecal S100A12 Protein Abnormal
- HLA B27 (Lab)
- HLA Specific association (Lab)
- Abnormal Lab Findings - Decreased
- Abnormal Lab Findings - Increased
- ASCA Positive (Antibodies yeast S Cerevisiae) (Lab)
- WBC
- CEA/Carcinoembryonic antigen (Lab)
- Eosinophiles (Lab)
- Globulin, serum (Lab)
- Haptoglobin, serum (Lab)
- IGA/Immunoglobulin A (Lab)
- Immune complex titer (Raji) (Lab)
- Leukocyte Alkaline phosphatase (Lab)
- Lysozyme/Muramidase (Lab)
- Monocytes (Lab)
- Monocytosis
- Platelet count (Lab)
- Sed Rate/ESR/Sedimentation rate (Lab)
- WBC/White Blood Cell Count/Leukocytes (Lab)
- STOOL Erythrocytes/RBCs
- STOOL Leukocytes
- STOOL Occult blood
Diagnostic Test Results[previous][top][next]
- Other Tests & Procedures
- Skin test anergy
- Colonoscopy/Abnormal
- Colonoscopy/Asymmetric disease pattern
- Colonoscopy/Cobblestone mucosa pattern
- Colonoscopy/Colon ulcers
- Colonoscopy/Longitudinal Fissuring
- Colonoscopy/Multiple ulcerations
- Colonoscopy/Nodular lesions, multiple
- Colonoscopy/Segmental colitis pattern
- Colonoscopy/Skip lesions/Ulcers
- Colonoscopy/Terminal ileum lesions
- Endoscopy/Small bowel flora increased/culture
- TEST/D-Xylose absorption abnormal
- Pathology
- BX/Intestinal Biopsy/Chronic inflammation
- BX/Intestinal Biopsy/Fibrosis edema
- BX/Intestinal biopsy/Granuloma
- BX/Intestinal biopsy/ileum/ abnormal
- BX/Intestinal biopsy/Jejunal/Abnormal
- BX/Intestinal Transmural lesions
- BX/Rectal biopsy/Abnormal
- PATH/Skip lesions/small bowel inflammation
- BX/Lymph node biopsy/Granulomatous changes
- BX/Liver biopsy/Granulomas in liver
- PATH/Granulomatous tissue/specimen
- CT Scan
- CT Scan/Abdomen abnormal
- CT Scan/Abdomen Cecum lesion
- CT Scan/Abdomen Colon thickened
- CT Scan/Abdomen Terminal ileum lesion
- CT Scan/Abdomen Terminal ileum skip lesions
- CT Scan/Double halo configuration lumen bowel/ABD
- CT Scan/Inflammatory mass peritoneal/ABD
- CT Scan/Mesenteric adenopathy/ABD
- CT Scan/Small bowel creeping mesenteric fat/ABD
- CT Scan/Thickened bowel wall/ABD
- CT Scan/Thickened/small-bowel wall/ABD
- X-RAY With contrast
- BE/Abnormality (barium enema)
- BE/Cecum contracted/conical (Xray)
- BE/Ileum contracted, fixed (Xray)
- BE/Ileum string sign (Xray)
- BE/Lesion of cecum (Xray)
- BE/Lesion of terminal ileum (Xray)
- BE/Long fistulous tract parallel to colon/bowel lumen
- BE/Nodular lymphoid follicular filling defects
- BE/Rectal deep collar button ulcers
- BE/Rectal sinus tracts
- BE/Rectovaginal fistula on barium enema (Xray)
- BE/Terminal ileum lesion (Xray)
- SBS/Abnormal Small Bowel Series
- SBS/Aphthous ulcers mucosa/small bowel
- SBS/Cobblestone mucosa/ulcerations
- SBS/Enterocutaneous fistula (Xray)
- SBS/Enteroenteric fistula (Xray)
- SBS/Enterovaginal fistula (Xray)
- SBS/Enterovesical fistula (Xray)
- SBS/Hose-like thickened bowel wall segment
- SBS/Intestine, segmental fixed narrowing (Xray)
- SBS/Mucosal destruction small bowel (Xray)
- SBS/Mucosal folds thickened, intestinal (Xray)
- SBS/Mucosal pattern irregular/swollen
- SBS/Multiple nodules/intestinal (Xray)
- SBS/Separation bowel loops (Xray)
- SBS/Straightening/rigidity small bowel loops
- SBS/String-sign small bowel (Xray)
- UGI/Duodenum dilatation
- UGI/Duodenum thickened folds
- UGI/Gastrocolic fistula
- UGI/Rugae enlarged/gastrum
- Ultrasound
- Other Tests & Procedures
Associated Diseases & Rule outs[previous][top][next]
- Rule Outs
- Abdominal actinomycosis
- Actinomycosis
- Adenocarcinoma, colon
- Amebiasis
- Anisakiasis
- Ankylosing spondylitis/Marie Strumple
- Appendicitis
- Campylobacter diarrhea
- Diverticulitis
- Dumping syndrome
- Gastroenteritis, acute infectious
- Gay bowel syndrome/proctitis
- Intestinal tuberculosis/enterocolitis/ileocecal
- Ischemic proctocolitis
- Pseudomembranous colitis/C difficile colitis
- Radiation Colitis
- Salmonella
- Shigella enteritis/bacillary dysentery
- Sprue (gluten enteropathy)
- Ulcerative colitis
- Whipple's disease
- Yersinia enterocolitis syndrome
- Associated Disease & Complications
- Abscess, intraperitoneal
- Abscess, ischiorectal
- Abscess, perianal/pararectal
- Adenocarcinoma, colon
- Amyloidosis, secondary
- Amyloidosis, systemic
- Anal fissure
- Anemia
- Anemia of chronic disease
- Anergic status
- Anorectal fistula
- Aphthous stomatitis/aphthous oral lesions
- Arthritis
- Arthritis of inflammatory bowel disease
- Bacteria intestinal overgrowth syndrome
- Blind-loop syndrome
- Bowel stricture
- Carcinoma, biliary tree
- Cholelithiasis
- Colitis
- Crohn's colitis/large bowel
- Crohns disease (regional enteritis)
- Cystitis
- Dehydration
- Encopresis/childhood
- Eosinophilia
- Erythema multiforme
- Erythema nodosum
- Fatty liver
- Fistula in ano
- Fistula, Colovesical
- Fistula, Cutaneous/enteric
- Fistula, Enteroenteric
- Fistula, Enterovaginal
- Fistula, Enterovesical
- Fistula, Gastroduodenal
- Fistula, Ileovesicular
- Fistula, Rectovaginal/colovaginal
- Focal GN/focal glomerulonephritis
- Folate deficiency
- Folic acid deficiency anemia
- Gastrointestinal bleeding
- Hypercalcuria
- Hypercoagulability/Thrombophilia
- Hypertrophic osteoarthropathy
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Hypovitaminosis B12
- Iatrogenic corticosteroid/treatment/effects
- Incomplete small bowel ostruction
- Inflammatory bowel disease
- Intestinal/bowel obstruction
- Intestinal/gut lymphoma
- Intraperitoneal abscess, Right lower quadrant
- Iritis
- Iron deficiency anemia
- Kidney stone/Nephrolithiasis/Urolithiasis
- Lactose intolerance syndrome
- Leukocytosis
- Lumbosacral arthritis/Spondylitis
- Malabsorption/Steatorrhea syndrome
- Mesenteric vein thrombosis
- Oxalate kidney stones
- Pelvis osteomyelitis
- Pericholangitis
- Perineal fistula
- Peritonitis. acute
- Polyarthritis syndrome/Multiple joints/weeks
- Proctitis
- Proctocolitis
- Protein losing enteropathy
- Psoas abscess
- Pyloric obtruction/stenosis
- Pyoderma gangrenosa
- Rectal stenosis/stricture
- Rectovesicular fistula
- Refractory iron deficiency anemia
- Sacroiliitis/Iliitis/Sacroiliac arthritis
- Scleritis/Episcleritis
- Short-bowel syndrome
- Small bowel obstruction
- Stomatitis
- Thrombocytosis
- Ulcer, anal/rectal
- Uveitis
- Vitamin B12 deficiency
- Granuloma Dermatitis
- Lower GI bleeding
- Recurrent GI bleed/elderly/no real source
- Small Intestine Bleeding
- Monoarthritis Acute
- PolyArthritis
- Calcium Containing Kidney Stones
- Disease Synergy - Causes
- Synergy/Non-steroid anti-inflammatory treatment
- Synergy/Oral contraceptive admin
- Synergy/Stress/Anxiety
- Synergy/Tobacco smoking
- Rule Outs
Disease Mechanism & Classification[previous][top][next]
- Class
- CLASS/Ileum involvement/manifestation
- CLASS/Intestinal/stomach/gut (category)
- Pathophysiology
- Pathophysiology/Gene card 15 mutation
- Pathophysiology/Gene locus Chromosome 16
- Pathophysiology/Gene locus Chromosome 6
- Pathophysiology/Gene Locus Identified/OMIM database
- Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
- Pathophysiology/Malabsorption folic acid
- Pathophysiology/NOD2 gene mutation/defect
- Pathophysiology/T-cell mediated/hypersens react/type 4
- Pathophysiology/Granulomatous skin areas/lesions
- Pathophysiology/B12 Intrinsic Factor receptors dys
- Pathophysiology/Delayed gastric emptying/gastrostasis
- Pathophysiology/Granulomatous intestinal/inflammation
- Pathophysiology/Ileal absorption impaired
- Pathophysiology/Intermittant partial bowel obstruction
- Pathophysiology/Malabsorption
- Pathophysiology/Small bowel bleeding source/adults
- Pathophysiology/Bile salt malabsorption
- Pathophysiology/Granulomatous liver disease
- Pathophysiology/Calcium containing kidney stone process
- Pathophysiology/Tumor necrosis factor activation effect
- Pathophysiology/Activated cellular immunopathology
- Process
- PROCESS/Allergy/collagen/autoimmune (category)
- PROCESS/Allergy/inflammatory/granulomatous disorder (ex).
- PROCESS/Eponymic (category)
- PROCESS/Ethnic predilection (ex)
- PROCESS/Inflammatory/Granulomatous disease (ex)
- PROCESS/Inflammatory/Granulomatous disorder (category)
- PROCESS/Granulomatous Disease
- Class
-
- Synonym
- Synonym/Regional enteritis (Crohns)
- Synonym/Regional ileitis (Crohn's disease)
- Synonym
Treatment[previous][top][next]
- Drug Therapy - Contraindication
- RX/Isotretinoin (Accutane)
- RX/Oral Retinoids
- Drug Therapy - Indication
- RX/Anti-TNF drug
- RX/Azathioprine (Imuran)
- RX/CA2 antibody (Inflixamab)
- RX/Ciprofloxacin (Cipro)
- RX/Clarithromycin (Biaxin)
- RX/Immune-suppression
- RX/Infliximab (Remicade)
- RX/Mesalamine (Asacol)
- RX/Metronidazol (Flagyl)
- RX/Multivitamin supplements
- RX/Natalizumab (Tysabri)
- RX/Olsalazine (Dipentum)
- RX/Omega/fish oil
- RX/Sulfasalazine(Azulfadine)
- Surgical Procedures or Treatments
- SX/Biopsy
- Other Treatments
- TX/Avoid caffeine
- TX/Total parenteral nutrition/TPN.
- Drug Therapy - Contraindication
External Links Related to Crohns disease (Regional enteritis)[previous][top]
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