Disease Information for Crohns disease (Regional enteritis)

Synonyms:

bowel regional enteritis, Cicatrizing enterocolitis, CROHN DISEASE, Crohn's disease (regional enteritis), Crohn's regional enteritis, eleocolitis, Enteritis regional, enteritis (regional), Enteritis Granulomatous, Enteritis Regional, Granulomatous enteritis, IBD1, INFLAMMATORY BOWEL DISEASE 1, INFLAMMATORY BOWEL DISEASE REGIONAL ENTERITIS, RE Regional enteritis, Regional enteritis, Regional enteritis Crohn, Regional enteritis Crohn's disease, Regional enteritis (Crohn's disease), Regional enteritis (disorder), Regional enteritis of unspecified site, regional enterocolitis

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Definition:

Crohn's disease is a chronic inflammatory disease of the intestines; It primarily causes ulcerations (breaks in the lining) of the small and large intestines, but can affect the digestive system anywhere from the mouth to the anus; It also is called granulomatous enteritis or colitis, regional enteritis, ileitis, or terminal ileitis;

Crohn's disease is related closely to another chronic inflammatory condition that involves only the colon called ulcerative colitis; Together, Crohn's disease and ulcerative colitis are frequently referred to as inflammatory bowel disease (IBD); Men and women are equally affected; IBD most commonly begins during adolescence and early adulthood, but it also can begin during childhood and later in life; Crohn's disease tends to be more common in relatives of patients with Crohn's disease; It also is more common among relatives of patients with ulcerative colitis;

The cause of Crohn's disease is unknown; Some scientists suspect that infection by certain bacteria, such as strains of mycobacterium, may be the cause of Crohn's disease; To date, however, there has been no convincing evidence that the disease is caused by infection; Crohn's disease is not contagious; Although diet may affect the symptoms in patients with Crohn's disease, it is unlikely that diet is responsible for the disease; In the early stages, Crohn's disease causes small, scattered, shallow, crater-like areas (erosions) on the inner surface of the bowel; These erosions are called aphthous ulcers; With time, the erosions become deeper and larger, ultimately becoming true ulcers (which are deeper than erosions) and causing scarring and stiffness of the bowel; As the disease progresses, the bowel becomes increasingly narrowed, and ultimately can become obstructed; Deep ulcers can puncture holes in the wall of the bowel, and bacteria from within the bowel can spread to infect adjacent organs and the surrounding abdominal cavity;

When Crohn's disease narrows the small intestine to the point of obstruction, the flow of the contents through the intestine ceases; Sometimes, the obstruction can be caused suddenly by poorly-digestible fruit or vegetables that plug the already-narrowed segment of the intestine; When the intestine is obstructed, digesting food, fluid and gas from the stomach and the small intestine cannot pass into the colon; The symptoms of small intestinal obstruction then appear, including severe abdominal cramps, nausea, vomiting, and abdominal distention; Obstruction of the small intestine is much more likely since the small intestine is much narrower than the colon to begin with; Deep ulcers can puncture holes in the walls of the small intestine and the colon, and create a tunnel between the intestine and adjacent organs; If the ulcer tunnel reaches an adjacent empty space inside the abdominal cavity, a collection of infected pus (an abdominal abscess) is formed; Patients with abdominal abscesses can develop tender abdominal masses, high fevers, and abdominal pain;

[Medicinenet_com 2007]

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