Disease Information for CREST syndrome

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Clinical Manifestations
Signs & Symptoms
Mask-like facies
Acrocyanosis/Cyanosis extremities
Regional pallor/vasospasm
Vasospasm of extremities/Signs
White/blanching area discoloration
Butterfly/hypopigmented area midback/scratch spared
Finger Lesions
Fingernails Telangiectasias
Telangiectasias, skin
Thickened skin/diffuse
Ulceration fingertips
Wooden Induration extremities
Finger tips/painful/tender
Hand Pain and Swelling Unilateral
Hand Pains
Inflammatory Finger Lesion
Multiple Digits Painful
Palmar Edema
Palmar Swelling
Telangiectasia Nailbeds
Unilateral Palmar Swelling
Hypesthesia
Hand pain and swelling bilateral
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Established Disease Population
Patient/Scleroderma
Laboratory Tests
Abnormal Lab Findings - Increased
Anti-SCL-70 (antinucleotide) (Lab)
ANA/Anti-centromere antibody (Lab)
Scleroderma Antibodies (SCL-70)
Diagnostic Test Results
X-RAY
Xray/Calcifications Subcutaneous
Xray/Calcification in fingertips
Xray/Calcifications of soft tissue, multiple
Xray/Soft tissue calcification/muscle/subcutaneous
Xray/Calcification soft tissues
Ultrasound
Echo/Pulmonary artery hypertension
Associated Diseases & Rule outs
Associated Disease & Complications
Acrosclerosis
Calcinosis
Collagen disease
Collagen vascular disease
Contractures/scars
Cor pulmonale
CREST syndrome
Esophageal hypomotility/effect
Esophageal motility disorder
Esophagitis, reflux/GERD
Gastrointestinal bleeding
Interstitial lung involvement/manifestation
Palmar fasciitis
Primary biliary cirrhosis
Pulmonary fibrosis
Pulmonary hypertension
Pulmonary hypertension, secondary
Raynaud's syndrome
Sclerodactyly
Scleroderma esophagus
Scleroderma renal disease
Telangiectasia
Disease Mechanism & Classification
Class
CLASS/Acronymic term disorder (ex)
CLASS/Dermatologic/Subcutaneous (category)
Pathophysiology
Pathophysiology/Calcifying deposition disorder
Pathophysiology/Calcific deposits/subcutaneous process
Pathophysiology/Exertional O2 desaturation
Pathophysiology/Metatopic/heterotopic calcification
Process
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Collagen disease (ex)
PROCESS/Complicating disorder (ex)
PROCESS/Complicating/Specific process disorder (ex)
PROCESS/Eponymic (category)
PROCESS/Metatopic disorder (ex)
PROCESS/Systemic illness (ex)
Synonyms
Synonym
Calc Rayn sclerodact oes telan, Calcinos, Raynaud, sclerodactyly, esophageal, telangiect, Calcinos, Raynaud, sclerodactyly, oesophageal, telangiect, Calcinosis cutis, Raynaud's, esophageal dysfunction, sclerodactyly AND telangiectasia, Calcinosis cutis, Raynaud's, oesophageal dysfunction, sclerodactyly and telangiectasia, Calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome, Calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome (disorder), Calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome, Calcinosis, Raynaud's phenomenon, sclerodactyly, esophageal dysfunction, telangiectasia syndrome, Calcinosis, Raynaud's phenomenon, sclerodactyly, oesophageal dysfunction, telangiectasia syndrome, CR(E)ST syndrome, CREST, CREST Calc Rayn scl oes tel, CREST Calc, Raynaud, sclerodact, oesoph, telangiect, CREST Calc,Rayn phen,oesoph dysf,sclerodact,telangiectasia, CREST Calcinosis Raynaud's phenomenon esophageal dysfunction sclerodactyly telangiectasia, CREST Calcinosis Raynaud's phenomenon oesophageal dysfunction sclerodactyly telangiectasia, CREST Calcinosis Raynaud's phenomenon sclerodactyly esophageal involvement telangiectasia syndrome, CREST Calcinosis Raynaud's phenomenon sclerodactyly oesophageal involvement telangiectasia syndrome, CREST syndrome, CREST syndrome (disorder), CREST VARIANT OF SCLERODERMA, Syndrome CREST, Synonym/Calcinosis/Rayn./Esoph mot/Sclerodact/Telang., Synonym/Calcinosis/Raynauds/sclerodactyly/telangiect, Synonym/Esophageal dysfunction/CRST syndrome, Synonym/Limited scleroderma/Variants, Synonym/Scleroderma, calcific variant
Definition

A form of systemic scleroderma usually less severe than other forms, consisting of calcinosis cutis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasis. That in which esophageal function is not prominent is known as CRST syndrome. (Dorland, 27th ed)

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External Links Related to CREST syndrome
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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