Disease Information for Craniorachischisis/Neural tube defect

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Clinical Manifestations
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Child
Population/Child-Infant Only
Population/Children/all
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Maternal MSAFP/Quad test (Inhibin A/HG/UE3/AFP)
Maternal triple test (APF/HG/Estriol) abnormal (labs)
Abnormal Lab Findings - Increased
Amniocentesis/Alfa-fetoprotein (AFP) Level
Amniotic fluid/Acetylcholinesterase level
Maternal AFP levels
Diagnostic Test Results
Other Tests & Procedures
Amniocentesis/Abnormality
CT Scan
MRI/Head Scan Abnormal
Associated Diseases & Rule outs
Associated Disease & Complications
Craniorachischisis/Neural tube defect
Spina bifida
Spina bifida occulta
Disease Mechanism & Classification
Class
CLASS/Midline structures/disorders (ex)
CLASS/Neurologic (category)
Process
PROCESS/Congenital/developmental (category)
PROCESS/Multiple dysmorphic syndrome (ex)
PROCESS/Anomalies/Deformities/Malformations (EX)
PROCESS/Congenital CNS disorder (ex)
Definition

neural tube defect includes anencephaly and skeletal defect including spina bifida and meningomyelocele;-----------------------------Defects of neural tube closure constitute some of the most common congenital malformations affecting the nervous system especially with folic acid deficiency states ans certain drugs; Spina bifida with associated meningomyelocele or meningocele is commonly found in the lumbosacral region; Depending on the extent and severity of the involvement of the spinal cord and peripheral nerves, lower extremity weakness, bowel and bladder dysfunction, and hip dislocation may be present; Early surgical closure of meningoceles and meningomyeloceles is usually indicated; Additional treatment is necessary to manage chronic abnormalities of the urinary tract, orthopedic abnormalities such as kyphosis and scoliosis, and paresis of the lower extremities; Hydrocephalus associated with meningomyelocele usually requires ventriculoperitoneal shunting-------------[Adapted Current DXRX Peds 2004]---------

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External Links Related to Craniorachischisis/Neural tube defect
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Wikipedia
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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