Disease Information for Colchicine Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Swelling/Puffy
Dizzy on Standing/Giddy Response
Low Blood Pressure
Orthostatic drop in blood pressure
Tachycardia/Fast heart rate
Acute Diarrhea
Acute Diarrhea in Elderly
Diarrhea
Diarrhea, explosive
Diarrhea, fulminant
Demographics & Risk Factors
Established Disease Population
Patient/Gout
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Macrocytosis/smear (Lab)
Toxin chromatography indentification/foods (Lab)
Abnormal Lab Findings - Decreased
Vitamin B12, serum (Lab)
Abnormal Lab Findings - Increased
MCV/Mean Corpuscular Volume (Lab)
Platelet count (Lab)
URINE Myoglobin
Diagnostic Test Results
Pathology
Bone Marrow/Maturation arrest/granulocytes
Associated Diseases & Rule outs
Associated Disease & Complications
Acute gastroenteritis
Agranulocytosis
Anemia, aplastic
Anogenital pruritis syndrome
Bone marrow failure/exhaustion
Colchicine effect/toxicity
Drug induced Diarrhea.
Drug induced Myelosuppression.
Drug induced Myopathy.
Drug induced Polymyositis syndrome.
Drug induced Thrombocytopenia.
Fetal anomaly
Granulocytopenia/Neutropenia
Hypotension
Hypovitaminosis B12
Inflammatory myopathy
Megaloblastic anemia/disease
Myelosuppression
Myoglobinuria
Myopathy/secondary/nonspecific
Orthostatic syncope Hypotension
Polymyositis
Pruritis ani
Rhabdomyolysis
Thrombocytopenia
Thrombocytosis
Vitamin B12 deficiency
Toxic Myopathy/Poisoning
Disease Mechanism & Classification
Drugs
DRUG/Anti-gout medication
DRUG/B12 absorption inhibition
DRUG/Mitotic inhibitor/spindle poison (ex)
DRUG/Narrow range of safety (effect/toxic)
DRUG/Teratogenic potential/effect (D plus )
DRUG/Teratogenic/OBGYN Class X/Pregnancy DANGER
DRUG/Fetal anomalies via father/sperm
Pathophysiology
Pathophysiology/Malabsorption B12
Pathophysiology/Third spacing fluid shift
Pathophysiology/Volume redistribution
Pathophysiology/B12 Intrinsic Factor receptors dys
Pathophysiology/Ileal absorption impaired
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Hemodialysis failure occurs
TOXIN/NOT Diagnosed on USUALToxic screens
TOXIN/Third spacing/Hemoconcentration
Synonyms
Synonym
(S) N (5,6,7,9 Tetrahydro 1,2,3,10 tetramethoxy 9 oxobenzoheptalen 7 yl)acetamide, Acetamide, N (5,6,7,9 tetrahydro 1,2,3,10 tetramethoxy 9 oxobenzo(a)heptalen 7 yl) , (S), COLCHCINE, COLCHICINE, Colchicine (product), Colchicine (substance), COLCHICINE PREPARATION, Colcichine, Brand name/Colcrys (Colchicine)
Treatment
Drug Therapy - Indication
DRUG-Herbal Anti-Gout claim
RX/AntiColchicine FAB antibodies
Drug Dosage
DRUG/Dose must be titrated to effect
DRUG/Dose single dose medication
DRUG/Generic available
DRUG/Oral medication (ex)
Definition

Anti-mitosis drug found naturally used in acute gout; oral and parenteral poreparation; renal damage with chronic use;

toxic agent in high dose; some specialized empiric use with amyloidosis and familial periodic fever and others

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External Links Related to Colchicine Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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