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Disease Information for Clozapine (Clozaril) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Seizures

Laboratory Tests

Abnormal Lab Findings - Increased

URINE Myoglobin

Associated Diseases & Rule outs

Associated Disease & Complications

Agranulocytosis

Cataplexy

Convulsions (grand mal)

Drug induced Neutropenia.

Enuresis, functional

Granulocytopenia/Neutropenia

Myocarditis, toxic

Myoglobinuria

Neuroleptic malignant syndrome

Obesity

Priapism/persistent erection

Rhabdomyolysis

Disease Mechanism & Classification

Drugs

DRUG/Antipsychotic/neuroleptic drug (example)

DRUG/Anti-Schizophrenia medication (example)

DRUG/Atypical anti-psychotic neuroleptic drugs

DRUG/Dibenzo-diazepine/Loxapine-like drug (example)

DRUG/Psychoactive/sedative drug (category)

DRUG/Safe in pregnancy patient (B)

DRUG/Lowers seizure threshold

Pathophysiology

Pathophysiology/Cytokine gene polymorphism

Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

5H Dibenzo(b,e)(1,4)diazepine, 8 chloro 11 (4 methyl 1 piperazinyl), clozapine, Clozapine (product), Clozapine (substance), CLOZAPINE PREPARATION, Brand name/Clozaril (Clozapine)

Treatment

Drug Dosage

DRUG/.$$$ Expensive medication

DRUG/.$$$$$ Most Expensive

DRUG/Dose 12.5 mgms (Unit/Pill/Capsule size)

DRUG/Dose 25 mgm (Unit/Pill/Capsule size)

DRUG/Dose BID Medication

DRUG/Dose must be titrated to effect

DRUG/Dose once daily (RX)

DRUG/Generic available

DRUG/Oral medication (ex)

DRUG/Restricted/controlled sales

Definition

Effective Anti-psychotic medication;indication in resistant schizophrenia; new class with neuroleptic overlap; oral preparation; main problem is blood dyscrasias with agranulocytosis on frequent basis; manufacturer requires weekly blood counts

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External Links Related to Clozapine (Clozaril) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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