Disease Information for Clozapine (Clozaril) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Seizures
Laboratory Tests
Abnormal Lab Findings - Increased
URINE Myoglobin
Associated Diseases & Rule outs
Associated Disease & Complications
Agranulocytosis
Cataplexy
Convulsions (grand mal)
Drug induced Neutropenia.
Enuresis, functional
Granulocytopenia/Neutropenia
Myocarditis, toxic
Myoglobinuria
Neuroleptic malignant syndrome
Obesity
Priapism/persistent erection
Rhabdomyolysis
Disease Mechanism & Classification
Drugs
DRUG/Antipsychotic/neuroleptic drug (example)
DRUG/Anti-Schizophrenia medication (example)
DRUG/Atypical anti-psychotic neuroleptic drugs
DRUG/Dibenzo-diazepine/Loxapine-like drug (example)
DRUG/Psychoactive/sedative drug (category)
DRUG/Safe in pregnancy patient (B)
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/Cytokine gene polymorphism
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
5H Dibenzo(b,e)(1,4)diazepine, 8 chloro 11 (4 methyl 1 piperazinyl), clozapine, Clozapine (product), Clozapine (substance), CLOZAPINE PREPARATION, Brand name/Clozaril (Clozapine)
Treatment
Drug Dosage
DRUG/.$$$ Expensive medication
DRUG/.$$$$$ Most Expensive
DRUG/Dose 12.5 mgms (Unit/Pill/Capsule size)
DRUG/Dose 25 mgm (Unit/Pill/Capsule size)
DRUG/Dose BID Medication
DRUG/Dose must be titrated to effect
DRUG/Dose once daily (RX)
DRUG/Generic available
DRUG/Oral medication (ex)
DRUG/Restricted/controlled sales
Definition

Effective Anti-psychotic medication;indication in resistant schizophrenia; new class with neuroleptic overlap; oral preparation; main problem is blood dyscrasias with agranulocytosis on frequent basis; manufacturer requires weekly blood counts

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External Links Related to Clozapine (Clozaril) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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