Disease Information for Clonidine (Catapres) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Breast Swelling Bilateral
Brief Blood pressure increase/sign:
High blood pressure/sign
Hypotension with Relative Bradycardia
Low Blood Pressure
Slow pulse/Bradycardia
Impotence, relative
Nausea
Vomiting
Fatigability
Stupor/poor reponse to stimulus
Apnea In Children
Bradypnea Decreased respiratory rate
Fatigue
Fatigue Tiredness Exhaustion
Dry eyes/poor tearing
Dryness Conjunctiva
Grainy/Gritty Eye Sensation
Miosis/narrow pupils
Night blindness/Impaired night vision
Typical Clinical Presentation
Coma with normal Head CT Scan
Clinical Presentation & Variations
Presentation/Rebound Hypertension after Drug Stopped
Laboratory Tests
Abnormal Lab Findings - Decreased
Plasma renin Activity/PRA (Lab)
Renin, serum (Lab)
Abnormal Lab Findings - Increased
Growth hormone/STH, plasma (Lab)
Diagnostic Test Results
EKG (ECG)
EKG/Widened QRS pattern (ECG)
EKG/AV Nodal Block/Complete
EKG/Sinus bradycardia (ECG)
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Rule Outs
Digitalis toxicity/poisoning
Associated Disease & Complications
Acute respiratory failure/Respiratory arrest
Bradyarrhythmias
Cardiac conduction defects
Central respiratory drive depression
Clonidine/alpha CNS agonist toxidrome
Drug Induced Fatigue
Drug induced Impotence.
Drug induced Rebound effect
Gynecomastia
Heart block, complete
Hypertension
Hypotension
Impotence/Erectile dysfunction disorder
Opiate/Morphine overdose toxidrome
Raynaud's syndrome
Sedation/torpor induced
Sinus bradycardia
Stokes-Adams attacks
Sympatholytic toxidrome/syndrome
Disease Mechanism & Classification
Drugs
DRUG/Alpha-2 adrenergic central agonist/effect
DRUG/Anti-addiction medication (example)
DRUG/Antiadrenergic agent (ex)
DRUG/Antihypertensive medication (examples)
DRUG/Central alpha/sympatholytic action drug (example)
DRUG/Chronic pain/Neuropathic pain adjunct medication
DRUG/Dangerous for kids (10Kg)/Very
DRUG/Important Acute care drugs (example)
DRUG/Sympatholytic effect
DRUG/Tolerance phenomenon occurs
DRUG/Withdrawal treatment
DRUG-Liver metabolism/bile excretion
Pathophysiology
Pathophysiology/CNS Respiratory Drive Center Suppressed
Pathophysiology/Tissue hypoxia/potential
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/ Hypertension/slow heart rate
TOXIN/Decreases Blood Pressure
TOXIN/Decreases Respiratory Rate
TOXIN/Hypotension relative bradycardia
TOXIN/Shock-hypovolemia effect.
TOXIN/Slow curve fast break 24 hrs
TOXIN/Venous pooling/low wedge press (ex).
Synonyms
Synonym
1H Imidazol 2 amine, N (2,6 dichlorophenyl) 4,5 dihydro, Clofenil, clonidine, Clonidine (product), Clonidine (substance), CLONIDINE PREPARATION, Klofenil, N (2,6 Dichlorophenyl) 4,5 dihydro 1H imidazol 2 amine, Brand name/Catapres (Clonidine), Brand name/Clorpres (Clonidine-Chlorthalidone) comb., Brand name/Combipres (Clonidine-Chlorthalidone), Brand name/Dixarit (Clonidine)
Treatment
Drug Therapy - Indication
RX/Naloxone (Narcan)
Drug Dosage
DRUG/.1990 or before
DRUG/Dose 0.1 mgm (Unit/Pill/Capsule size)
DRUG/Dose 0.2 mgm (Unit/Pill/Capsule size)
DRUG/Dose 0.3 mgm (Unit/Pill/Capsule size)
DRUG/Dose BID Medication
DRUG/Dose Dermal patch delivery
DRUG/Dose TID Medication
DRUG/Generic available
DRUG/Oral medication (ex)
Herbal Dose BID
Definition

Anti-hypertensive drug. Alpha-2 CNS (Central) adrenergic agonist mechanism. Oral and dermal patch drug. Used for

addiction disorders and withdrawal syndromes.active through the opiate receptor system; helps some withdrawal syndromes but itself often included in overdose (long acting)

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External Links Related to Clonidine (Catapres) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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