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Disease Information for Clonidine (Catapres) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Breast Swelling Bilateral

Brief Blood pressure increase/sign:

High blood pressure/sign

Hypotension with Relative Bradycardia

Low Blood Pressure

Slow pulse/Bradycardia

Stupor/poor reponse to stimulus

Apnea In Children

Bradypnea Decreased respiratory rate

Fatigue

Fatigue Tiredness Exhaustion

Dry eyes/poor tearing

Dryness Conjunctiva

Grainy/Gritty Eye Sensation

Miosis/narrow pupils

Night blindness/Impaired night vision

Typical Clinical Presentation

Coma with normal Head CT Scan

Clinical Presentation & Variations

Presentation/Rebound Hypertension after Drug Stopped

Laboratory Tests

Abnormal Lab Findings - Decreased

Plasma renin Activity/PRA (Lab)

Renin, serum (Lab)

Abnormal Lab Findings - Increased

Growth hormone/STH, plasma (Lab)

Diagnostic Test Results

EKG (ECG)

EKG/Widened QRS pattern (ECG)

EKG/AV Nodal Block/Complete

EKG/Sinus bradycardia (ECG)

EKG/Changes/abnormalities (ECG)

Associated Diseases & Rule outs

Rule Outs

Digitalis toxicity/poisoning

Associated Disease & Complications

Acute respiratory failure/Respiratory arrest

Bradyarrhythmias

Cardiac conduction defects

Central respiratory drive depression

Clonidine/alpha CNS agonist toxidrome

Drug Induced Fatigue

Drug induced Impotence.

Drug induced Rebound effect

Gynecomastia

Heart block, complete

Hypertension

Hypotension

Impotence/Erectile dysfunction disorder

Opiate/Morphine overdose toxidrome

Raynaud's syndrome

Sedation/torpor induced

Sinus bradycardia

Stokes-Adams attacks

Sympatholytic toxidrome/syndrome

Disease Mechanism & Classification

Drugs

DRUG/Alpha-2 adrenergic central agonist/effect

DRUG/Anti-addiction medication (example)

DRUG/Antiadrenergic agent (ex)

DRUG/Antihypertensive medication (examples)

DRUG/Central alpha/sympatholytic action drug (example)

DRUG/Chronic pain/Neuropathic pain adjunct medication

DRUG/Dangerous for kids (10Kg)/Very

DRUG/Important Acute care drugs (example)

DRUG/Sympatholytic effect

DRUG/Tolerance phenomenon occurs

DRUG/Withdrawal treatment

DRUG-Liver metabolism/bile excretion

Pathophysiology

Pathophysiology/CNS Respiratory Drive Center Suppressed

Pathophysiology/Tissue hypoxia/potential

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Toxin

TOXIN/ Hypertension/slow heart rate

TOXIN/Decreases Blood Pressure

TOXIN/Decreases Respiratory Rate

TOXIN/Hypotension relative bradycardia

TOXIN/Shock-hypovolemia effect.

TOXIN/Slow curve fast break 24 hrs

TOXIN/Venous pooling/low wedge press (ex).

Synonyms

Synonym

1H Imidazol 2 amine, N (2,6 dichlorophenyl) 4,5 dihydro, Clofenil, clonidine, Clonidine (product), Clonidine (substance), CLONIDINE PREPARATION, Klofenil, N (2,6 Dichlorophenyl) 4,5 dihydro 1H imidazol 2 amine, Brand name/Catapres (Clonidine), Brand name/Clorpres (Clonidine-Chlorthalidone) comb., Brand name/Combipres (Clonidine-Chlorthalidone), Brand name/Dixarit (Clonidine)

Treatment

Drug Therapy - Indication

RX/Naloxone (Narcan)

Drug Dosage

DRUG/.1990 or before

DRUG/Dose 0.1 mgm (Unit/Pill/Capsule size)

DRUG/Dose 0.2 mgm (Unit/Pill/Capsule size)

DRUG/Dose 0.3 mgm (Unit/Pill/Capsule size)

DRUG/Dose BID Medication

DRUG/Dose Dermal patch delivery

DRUG/Dose TID Medication

DRUG/Generic available

DRUG/Oral medication (ex)

Herbal Dose BID

Definition

Anti-hypertensive drug. Alpha-2 CNS (Central) adrenergic agonist mechanism. Oral and dermal patch drug. Used for

addiction disorders and withdrawal syndromes.active through the opiate receptor system; helps some withdrawal syndromes but itself often included in overdose (long acting)

(Edit)

External Links Related to Clonidine (Catapres) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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