Disease Information for Vitamin B12 deficiency (Clinical Manifestations)
Cobalamin deficiency, Cobalamin deficiency (disorder), cyanocobalamin deficiency, DEFIC VITAMIN B 12, DEFIC VITAMIN B12, Deficiencies Vitamin B12, deficiency cyanocobalamin, Deficiency of vitamin B12, Deficiency of vitamin B12 (disorder), Deficiency Vitamin B 12, deficiency vitamin B12, VITAMIN B 12 DEFIC, VITAMIN B 12 DEFICIENCY, VITAMIN B A 12 DEFICIENCY, VITAMIN B12 DEFIC, Vitamin B12 Deficiencies, vitamin B12 deficiency, Vitamin B12 deficiency disease, vitamin deficiency B12
A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia; Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations; A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis; (From Cecil Textbook of Medicine, 19th ed, p848)-------------------------------------------------Vitamin B12 Deficiency ;Cobalamin Deficiency;<br>
Vitamin B12 Deficiency is characterized by an abnormally low blood levels of this vitamin; The disorder can be caused by a poor diet, inadequate absorption or utilization of B12 that may follow stomach and intestinal surgery or an increase in certain intestinal organisms; The deficiency causes changes in the blood and the central nervous system; Injection of this vitamin usually cures the disorder if the underlying cause can be corrected-------------[NORD 2005]---------------
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Clinical Manifestations
- Signs & Symptoms
- Gray Hair
- Grey hair Childhood
- Grey hair, premature
- Hyperpigmented discrete macules/palms/soles
- Increased pigmentation/tanning/hyperpigmented
- Pigmented lines/fingernails
- Pigmented/skin folds/flexor/palmar creases
- White Hair
- Anorexia Decreased appetite
- Anorexia in Elderly
- Malnourished/poor nutrition status/signs
- Buccal pigmentations
- Decreased taste ability/Hypoguesia
- Oral pigmentation lesions
- Tongue lesion/sign
- Acroparesthesias Acral Paresthesias
- Leg cramps,nocturnal
- Ataxia
- Ataxia
- Ataxia/Posterior columns
- Focal neurologic deficit
- Hypesthesia
- Hyporeflexia/DTRs decreased
- Lhermittes sign (tingling on neck flex)
- Loss of Taste
- Paresthesias
- Personality change
- Sensory Ataxia
- Staggering Gait
- Symmetric Polyneuropathy
- Anosmia/Loss of sense of smell
- Clinical Presentation & Variations
- Disease Progression
- Pancytopenia with Normal Marrow
- Signs & Symptoms
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