Disease Information for Progressive leukoencephalopathy/multifo (Clinical Manifestations)

ENCEPH JC POLYOMAVIRUS, Encephalitis JC Polyomavirus, Encephalopathies JC Polyomavirus, Encephalopathy JC Polyomavirus, JC POLYOMAVIRUS ENCEPH, JC Polyomavirus Encephalitis, JC Polyomavirus Encephalopathy, LEUKOENCEPH PROGRESSIVE MULTIFOCAL, Leukoencephalopathies Progressive Multifocal, leukoencephalopathy multifocal, Leukoencephalopathy Progressive Multifocal, Multifocal leucoencephalopathy, Multifocal Leukoencephalopathies Progressive, Multifocal leukoencephalopathy, Multifocal Leukoencephalopathy Progressive, PML, PML Prog multifo leukoenceph, PML Progressive multifocal leucoencephalopathy, PML Progressive multifocal leukoencephalopathy, PMLE Prog multi leucoenceph, PMLE Progressive multifocal leucoencephalopathy, PMLE Progressive multifocal leukoencephalopathy, Prog mltifoc lucoencephalopath, Progressive multifocal leucoencephalopathy, PROGRESSIVE MULTIFOCAL LEUKOENCEPH, Progressive Multifocal Leukoencephalopathies, Progressive multifocal leukoencephalopathy, Progressive multifocal leukoencephalopathy (disorder)

Progressive multifocal leukoencephalopathy is a demyelinating CNS disorder with a propensity for affliction of immunosuppressed adults, especially AIDS patients; The cause is JC virus (JCV), a papovavirus that targets myelinating oligodendrocytes of the CNS; PCR of the cerebrospinal fluid for JCV is used for diagnosis in patients with compatible clinical and radiologic findings; HAART for HIV infection is often effective in improving survival as well as the clinical and radiographic features associated with this disease; Other agents used include cidofovir, not routinely recommended, and topotecan, which appears to be of some benefit; Progressive multifocal leukoencephalopathy (PML) should not be confused with Creutzfeldt-Jakob disease despite the similar initials of the causative agents--------------[Current Medical DX RX 2005]-----------------------------------

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