Disease Information for Physostigmine (Eserine/Antlirium) Administration/Toxicity (Clinical Manifestations)
physostigmine, Physostigmine (product), Physostigmine (substance), PHYSOSTIGMINE PREPARATION, Pyrrolo(2 3 b)indol 5 ol 1 2 3 3a 8 8a hexahydro 1 3a 8 trimethyl methylcarbamate (ester) (3aS cis)
ACH Inhibitor drug; Anticholinesterase inhibitor used in<br>
drug toxicity anticholinergics/atropine/TCA and topically for glaucoma; oral and parenteral and topical ophthalmic preparations (miotic) drug; ActylCholine esterase inhibitors can cause cholinergic crisis; short half life precludes myasthenia treatment<br>
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Clinical Manifestations
- Signs & Symptoms
- Low Blood Pressure
- Orthostatic drop in blood pressure
- Regional pallor/vasospasm
- Slow pulse/Bradycardia
- Vasospasm of extremities/Signs
- Diaphoresis profuse/active sweating/acute
- Hyperhidrosis/Chronic sweating excess
- Sweating Excess Perspiration
- Abdominal Pain
- Active Bowel Sounds
- Borborygmi/Bowel sound increased
- Colicky Abdominal Pain
- Diarrhea
- Diarrhea, explosive
- Diarrhea, fulminant
- Loss of bowel control/incontinence acute
- Nausea
- Vomiting
- Seizures
- Bronchospasm signs
- Wheezing
- Cholinergic symptoms/signs
- Infrequent blinking/Stellwag sign
- Lacrimation/excess tearing
- Miosis/narrow pupils
- Tearing
- Typical Clinical Presentation
- Coma with cholinergic ( SLUD) signs
- Signs & Symptoms
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