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Disease Information for Pernicious anemia: Clinical Manifestations

Signs & Symptoms: Palpitations/Skipped beats; Tachycardia/Fast heart rate
: Baldness/Alopecia; Depigmented patches, skin; Gray Hair; Gray hair Childhood; Gray hair, premature; Hair loss; Hyperpigmented discrete macules/palms/soles; Increased pigmentation/tanning/hyperpigmented; Non-scarring Alopecia/balding; Petechiae/Petechial rash; Pigmented/skin folds/flexor/palmar creases; Purpura; Silvery gray hair/child; White Hair; Yellow skin discoloration
: Anemia symptoms/chronic
: Abdominal Pain; Anorexia Decreased appetite; Anorexia in Elderly; Dyspepsia; Epigastric Pain; Epigastric recurrent pain attacks; Gastric symptoms/signs; Indigestion; Vague GI symptoms/persistent
: Altered taste/Taste perception; Burning/sore tongue (glossodynia/glossopyrosis); Mouth/tongue/lips burning pain; Oral mucosa erythematous lesions; Red Tongue; Red/glazed/Bald tongue; Smooth tongue; Sore/Painful mouth; Tongue lesion/sign
: Palpable Liver/Hepatomegaly; Yellow skin/white sclera
: Acroparesthesias Acral Paresthesias; Flabby muscles; Leg cramps,nocturnal; Muscle weakness; Numbness of feet; Weak/Weak as a kitten (symptom)
: Altered mental status Mental status change; Apathy/Indifference; Arm vibratory sense decreased; Ataxia; Ataxia is worse at night; Ataxia/Posterior columns; Babinski's upgoing toes/bilateral; Behavior problems; Cognitive deficit/mild; Confusion/agitation on exam; Confusion/Disoriented; Delirium; Delirium/Agitated delirium; Dizziness/Dizzy; Dysesthesias; Fine-motor coordination problems; Glove/stocking hypesthesia; Hung reflexes (prolonged relaxation)/Woltman sign; Hypesthesia; Hyporeflexia/DTRs decreased; Impaired judgement/signs; Lhermittes sign (tingling on neck flex); Mental Slowing Deteriation; Motor slowing; Paresthesias; Personality change; Poor coordination legs/feet; Position sense decreased/proprioception; Position sense decreased/proprioception Legs; Romberg sign positive; Sensory Ataxia; Spastic paralysis/signs; Staggering Gait; Sudden unconsciousness; Symmetric Polyneuropathy; Unable to tandem walk/straight line; Vertigo; Vibratory sense decreased; Vibratory sense decreased Legs
: Dyspnea on exertion
: Depressed/discouraged/sad; Hallucination/visual; Psychiatric manifestations/problems/difficulties; Psychotic behavior/symptomatic
: Anosmia/Loss of sense of smell; Decreased sense of smell
: Splenomegaly
: Chronic Fatigue; Enervated/extreme acute fatigue; Falling; Fatigue Tiredness in Elderly; Listlessness/lassitude; Mucous membrane pallor; Pallor; Pallor, waxy lemon yellow; Walking difficulties; Weakness; Weakness non-neuromuscular/systemic; Weight Loss
: Central Vision Loss/Scotoma; Conjunctival pallor; Roth spots in fundi
: Big ears; Prominent Ears; Tinnitus; Tinnitus in Elderly
Typical Clinical Presentation: Hypokalemia/complicating treatment; Presentation/Scandinavian elderly with anemia, chronic
Clinical Presentation & Variations: Anemia with Low Reticulocyte Count; Presentation/Anemia Chronic Severe Not too sick; Presentation/Anemia Severe Chronic Young Woman; Presentation/Anemia Severe Not too Sick; Presentation/Anemia Young Black Woman; Presentation/Anemia Young Hispanic Woman; Presentation/Scandinavian Woman Anemia Neurologic Symptoms
: Presentation/Progressive Motor Sensory Polyneuropathy
: Presentation/Color Blindness Acquired
Disease Progression: Onset/insidious
: Pancytopenia with Hypercellular Marrow; Pancytopenia with Normal Marrow

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