Disease Information for Human Herpes Virus 7/Roseola Infantum agent (Clinical Manifestations)

B Lymphotropic Virus Human, B Lymphotropic Viruses Human, Exanthem subitum virus, HBLV, herpes simplex virus type 6, herpesvirus 6 HHV 6, Herpesvirus 6 Human, HERPESVIRUS HUMAN 06, Herpesvirus type 6, HHV 6, HHV6, HHV6 Human herpes virus 6, Human B Lymphotropic Virus, Human B Lymphotropic Viruses, Human herpes virus 6, HUMAN HERPESVIRUS 06, human herpesvirus 6, Human herpesvirus 6 (organism), human herpesvirus 6 HHV 6, Human herpesvirus type 6, human herpesvirus type 6 HHV 6, HUMAN LYMPHOTROPIC VIRUS AB, Roseola infantum virus, Roseola virus, Virus HHV6

HHV-7 was discovered in 1990 and is member of the betaherpesvirus family, closely related to both HHV-6 and cytomegalovirus (CMV);Of the 3 viruses, HHV-7 is the least pathogenic; Like its cousin HHV-6, an HHV-7 primary infection causes roseola infantum in infants and young children, which is an undifferentiated, febrile illness that typically lasts for 6 days; Symptoms include a rash on the neck and trunk, as well as mild upper respiratory infection and cervical lymphadenopathy; Complications include febrile seizures, meningitis and encephalitis, as well as neurological complications (in individuals with active CNS infection); Otitis and gastroenteritis have also been reported in these patients;HHV-7 is typically acquired prior to age 5, and is thought to affect over 95% of the population; After primary infection, HHV-7 establishes latency in the host, which predisposes individuals to reactivation during periods of time when their immune systems are not functioning properly; Because the rate of prevalence of HHV-7 is so high in the general population, it is thought that viral reactivation or enhancement of replication takes place after a liver transplant, due to the immunocompromised nature of the human host in the period of time immediately after transplant; The incidence of HHV-7 infections post liver transplantation has been reported to be as high as 45%; Reactivation typically takes place within 2-8 weeks after the transplant; Post-transplant infections have also been documented in BMT patients;

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