Disease Information for Hemorrhagic fever, Crimea-Congo (Clinical Manifestations)

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A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus; incubation 2-9 days;major hemorrhagic and liver involvement, minor encephalitis, absent nephropathy;--------------------------------------------CRIMEAN-CONGO HEMORRHAGIC FEVER Crimean-Congo hemorrhagic fever is a serious tick-borne and potentially fatal illness that is acquired directly from tick bites or from contact with or aerosol transmission by blood from infected animals, but this disease also poses a significant threat for nosocomial transmission; Onset is usually abrupt with severe headache, high fever, myalgia, weakness, anorexia, back and abdominal pain, and nausea often accompanied by vomiting; There is hyperemia, which is most notable on the face, mucous membranes, and upper part of the body; The illness generally has a biphasic course: early nonspecific symptoms are followed after the sixth day of illness by hemorrhage from the nose, mouth, and gastrointestinal tract, and the appearance of large ecchymotic areas on the limbs; Most cases are apathetic or obtunded with halting speech; dizziness and mild meningeal signs are common; Elevated bilirubin and liver enzyme levels are usually present; Severe cases are delirious or comatose, and death is the consequence of circulatory collapse and disseminated intravascular coagulation----------------- [Rudolph"s Pediatrics 2002]--------------------------

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