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Disease Information for Fatty liver of pregnancy, acute (Clinical Manifestations)

Synonyms:

Acute fatty liver of pregnancy, AFLP Ac fatty liver of pregn, AFLP Acute fatty liver of pregnancy, Fatty liver of pregnancy, FATTY LIVER OF PREGNANCY ACUTE

Acute fatty liver of pregnancy (AFLP) is a syndrome that occurs late in pregnancy and is often associated with jaundice and hepatic failure; The liver is typically small; AFLP is more common when the mother is carrying a male fetus and may be associated with a deficiency of long-chain-3-hydroxy acyl COH dehydrogenase; AFLP usually necessitates termination of pregnancy due to the risk of rapid and fatal deterioration; Preeclampsia or the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP), which may complicate eclampsia, presents in a similar fashion and progresses to severe liver dysfunction, though typically with a normal size liver; Aminotransferase elevations are typically modest in all of these conditions (generally <500); If diagnosed in time, the disease usually resolves with termination of the pregnancy; Recurrence in subsequent pregnancies is rare; Microvesicular fat accumulation also may be seen as a toxic reaction to valproic acid and with excessive doses of tetracycline ; It is a typical finding in Jamaican vomiting sickness, which is caused by hypoglycin A present in unripened ackee fruit; The combination of lactic acidosis and severe liver injury with microvesicular fat has been described as a complication of nucleoside analogue therapy; --------------(Harrisons 2004)-----------

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