Disease Information for Craniopharyngioma (Clinical Manifestations)

Synonyms:

ADAMANTINOMA, PITUITARY, BRAIN TUMOR, CRANIOPHARYNGIOMA, Craniopharyngioma, Craniopharyngioma (disorder), Craniopharyngioma (morphologic abnormality), Craniopharyngiomas, INTRACRANIAL NEOPLASM, CRANIOPHARYNGIOMA, NEOPL RATHKE CLEFT, NEOPL RATHKES CLEFT, Neoplasm of Rathke's Pouch, Neoplasm, Rathke Cleft, Neoplasm, Rathkes Cleft, Neoplasm, Rathke's Cleft, PITUITARY EPIDERMOID TUMOR, RATHKE CLEFT NEOPL, Rathke Cleft Neoplasm, RATHKE POUCH TUMOR, RATHKES CLEFT NEOPL, Rathkes Cleft Neoplasm, Rathke's Cleft Neoplasm, Rathke's Pouch Neoplasm, Rathkes Pouch Tumor, Rathke's pouch tumor, Rathke's pouch tumour, Tumor of Rathke's Pouch, tumor Rathke's pouch, Tumor, Rathke Pouch, Tumor, Rathke's Pouch

A benign brain tumor that may be considered malignant because it can damage the hypothalamus; Usually presents insidiously in teenager or old child with growth hormone deficiency, obstructive hydrocephalus, short term memory loss, and psychomotor slowing; Sex incidence is equal; Common pediatric non-glial brain tumor; Often diabetes insipidus and dwarfism as well as headache with bitemporal hemianopsia; This is 3-5% of all pediatric brain tumors; bimodal peaks of incidence first and second decade and then in sixth decade; Treatment is surgery and radiation with relapse 30-50 percent of cases; These tumors arise in a squamous remnant of Rathke"s Pouch located in infundibulum or upper anterior hypophysis; Nests of squamous cells are commonly found in normal patients in suprasellar area surrounding the pas tuberalis of the adult pituitary;<br>

Prognosis guarded, Relapse and regrowth occurs 30 to 50%; operative mortality 5-15%, 5 year survival 88% maximum<br>

---------[Ferri Clinical advisor]-------------

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Clinical Manifestations
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  - Onset/gradual
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  - Onset/Second decade
  - Galactorrhea

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