Disease Information for Cisplatin (Platinol) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Dizzy on Standing/Giddy Response
Orthostatic drop in blood pressure
Facial erythema
Facial flushing/Beet red
Flushing
Flushing/upper body
Bilateral Calf Pains
Leg cramps,nocturnal
Leg cramps/muscle spasm/pains
Motor and sensory neuropathy/Polyneuropathy signs
Papilledema on exam
Paresthesias
Acute Hearing Loss
Sudden deafness
Typical Clinical Presentation
Presentation/Anaphylaxis with first dose/medication
Laboratory Tests
Abnormal Lab Findings - Decreased
Magnesium (Lab)
Abnormal Lab Findings - Increased
Magnesium (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Anaphylactoid reaction/Non-IGE/Very first dose
Anaphylaxis, generalized
Angioedema/angioneurotic edema
Ataxic neuropathy
Deafness, sensorineural
Drug Allergy
Drug induced Hypomagnesemia
Drug Induced Infusion Reaction
Drug induced Neutropenia.
Drug induced Peripheral neuropathy.
Drug induced Renal failure,
Fetal anomaly
Granulocytopenia/Neutropenia
Hemolytic-uremic syndrome
Hypomagnesemia
Magnesium deficiency
Nephrogenic diabetes insipidus
Orthostatic syncope Hypotension
Pancreatitis, acute
Peripheral neuropathy
Polyneuritis
Red Man Syndrome
Toxic peripheral/polyneuropathy
Polyneuropathy
Deafness Acquired
Disease Mechanism & Classification
Drugs
DRUG/Alkylating agents (example)
DRUG/Chemotherapeutics/cancer drugs/etc (category)
DRUG/CMV ChemoRX protocol (comb)
DRUG/First dose caution
DRUG/H-CAP protocol (four drugs) (comb)
DRUG/M-VAC ChemoRx protocol (comb)
DRUG/Platinum Chemotherapy agents
DRUG/Teratogenic potential/effect (D plus )
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Causes Flushing/Redness
Synonyms
Synonym
(SP 4 2) Diamminedichloroplatinum, CACP, CDDP, CDDP Cisplatin, cis DDP, cis Diaminedichloroplatinum, cis diammine dichloroplatinum, Cis diamminedichloridoplatinum, Cis diamminedichloro Platinum (II), cis Diamminedichloroplatinum, cis Diamminedichloroplatinum(II), Cis dichloroammine Platinum (II), cis dichlorodiammineplatinum, cis Dichlorodiammineplatinum(II), Cis platinous Diamine Dichloride, cis Platinum, cis platinum compound, Cis platinum II, Cis platinum II Diamine Dichloride, Cismaplat, Cisplatin, Cisplatin (product), Cisplatin (substance), CISPLATIN PREPARATION, Cisplatin product, Cisplatina, Cisplatinum, CPDD, Cysplatyna, DDP, Diaminedichloroplatinum, Diaminedichloroplatinum (substance), DIAMMINEDICHLOROPLATINUM CIS 02, Diamminodichloride, Platinum, Dichlorodiammineplatinum, DICHLORODIAMMINEPLATINUM CIS 02, PDD, Peyrone's Chloride, Peyrone's Salt, Platinoxan, platinum diamminodichloride, Platinum, Diaminedichloro , cis (8CI), Platinum, diamminedichloro , (SP 4 2), Brand name/CDDP (Cisplatin), Brand name/Platinol (Cisplatin), GEM-P Chemotherapy regimen
Treatment
Drug Dosage
DRUG/Dose small test-dose method
DRUG/Dose Unit dose Vial preparation
Definition

Platinum toxic effect drug. Primarily an Antineoplastic cancer chemotherapy drug. Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell devision. Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often.

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External Links Related to Cisplatin (Platinol) Administration/Toxicity
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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