Disease Information for Chronic Inflammatory Demyelinating Polyneuropathy (CIDIP)

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Clinical Manifestations
Signs & Symptoms
Acute Motor Weakness
Distal Muscle Weakness
Distal upper extremity weakness
Hypotonia
Absent knee reflexes
Ankle reflexes decreased
Ataxia
Hyporeflexia/DTRs decreased
Motor and sensory neuropathy/Polyneuropathy signs
Paralysis
Sensory Ataxia
Staggering Gait
Symmetric Polyneuropathy
Distal Hyperlaxity
Marcus-Gunn pupil reaction/consensory sign
Clinical Presentation & Variations
Presentation/Progressive Motor Sensory Polyneuropathy
Disease Progression
Course/Chronic disorder
Course/Chronic only
Laboratory Tests
Abnormal Lab Findings - Increased
Anti-Sulfatide Antibody (labs)
Peripheral neural antibody titer
CSF IGG synthesis rate
Diagnostic Test Results
Other Tests & Procedures
Lumbar puncture/abnormal
Pathology
BX/Nerve biopsy/abnormal
BX/Nerve biopsy/Inflammatory demyelination
BX/Nerve biopsy/Patchy demyelination/peripheral nerves
Electrodiagnosis
EMG/NCS Demyelination pattern
EMG/NCS Prolonged distal latencies
EMG/NCS Slowing
Associated Diseases & Rule outs
Rule Outs
Amyotrophic lateral sclerosis
Diabetic peripheral neuropathy
Eaton-Lambert syndrome
Lead toxicity/poisoning
Multiple sclerosis
Peroneal muscular atrophy/Charcot Marie Tooth
Associated Disease & Complications
Inflammatory Polyneuropathy Syndrome
Inflammatory polyneuropathy/demyelinating/chronic
Mononeuritis, multiplex
Motor neuropathy
Multi-radicular Polyneuropathy syndrome
Polyneuritis
Ataxia Disorder
Demyelinating Disease
Mononeuropathy
Disease Mechanism & Classification
Class
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Acquired Neuropathy
Pathophysiology/Delayed nerve conduction velocity
Pathophysiology/Demyelinating Spares Brain
Pathophysiology/Demyelination
Pathophysiology/Peripheral neurologic myelinopathy
Pathophysiology/Polyradiculneuropathy demyelininating
Process
PROCESS/Autoimmune disorder (ex)
PROCESS/Use/Age/atrophic disorder (category)
PROCESS/CNS/White matter disorder (ex)
PROCESS/Mononeuropathy tendency (ex)
PROCESS/Myelin involvement/disorder (ex)
Synonyms
Synonym
Chr infl demyel plyradiculoneu, CHRONIC INFLAMM DEMYELINATING POLYRADICULONEUROPATHY, CHRONIC INFLAMM POLYRADICULONEUROPATHY, Chronic inflammatory demyelinating polyradiculoneuropathy, Chronic inflammatory demyelinating polyradiculoneuropathy (disorder), Chronic Inflammatory Polyradiculoneuropathies, Chronic Inflammatory Polyradiculoneuropathy, Chronic Inflammatory Polyradiculopathies, Chronic Inflammatory Polyradiculopathy, CIDP, CIDP Chronic inflammatory demyelinating polyradiculoneuropathy, CIDP chr infl demyel polyradic, CIDP chr inflammatory demyelinating polyradiculoneuropathy, INFLAMM POLYRADICULOPATHY CHRONIC, Inflammatory Polyradiculopathies Chronic, Inflammatory Polyradiculopathy Chronic, POLYNEUROPATHY INFLAMMATORY DEMYELINATING CHRONIC, Polyradiculoneuropathies Chronic Inflammatory, POLYRADICULONEUROPATHY CHRONIC INFLAMM, POLYRADICULONEUROPATHY CHRONIC INFLAMM DEMYELINATING, Polyradiculoneuropathy Chronic Inflammatory, Polyradiculoneuropathy Chronic Inflammatory Demyelinating, Polyradiculopathies Chronic Inflammatory, Polyradiculopathy Chronic Inflammatory, Synonym/CIDP/demyelinating polyradiculoneuritis, Synonym/Demyelinating polyradiculoneuop/chr/inflam.
Treatment
Drug Therapy - Indication
RX/Immunoglobulin infusion
SX/Nerve biopsy
Other Treatments
TX/Plasma exchange/FFP
TX/Plasmapheresis/exchange.
Definition

Chronic Inflammatory Demyelinating Polyneuropathy

Other names or spellings: CIDP, chronic relapsing polyneuropathy; Chronic condition damaging peripheral nerves; Parent types of Chronic Inflammatory Demyelinating Polyneuropathy: Demyelinating disorder; Organs Affected by Chronic Inflammatory Demyelinating Polyneuropathy: nerves, arms, legs, toes, fingers; More common in young adults, but any age possible,and in both genders, CIDP is more common in young adults, and in men more so than women;

Prognosis of Chronic Inflammatory Demyelinating Polyneuropathy: The course of CIDP varies widely among individuals; Some may have a bout of CIDP followed by spontaneous recovery, while others may have many bouts with partial recovery in between relapses; The disease is a treatable cause of acquired neuropathy and initiation of early treatment to prevent loss of nerve cells is recommended; However, some individuals are left with some residual numbness or weakness; Complications of Chronic Inflammatory Demyelinating Polyneuropathy; symptoms of Chronic Inflammatory Demyelinating Polyneuropathy: List of symptoms of Chronic Inflammatory Demyelinating Polyneuropathy: Slowly progressive weakness and sensory dysfunction of the legs and arms; Tingling in toes and fingers; Numbness in toes and fingers; Weakness of the arms and legs; Aching muscle pain; Loss of deep tendon reflexes (areflexia); Fatigue; Abnormal sensations; Treatments: Corticosteroids; Prednisone; Immunosuppressant drugs; Plasmapheresis (plasma exchange); Intravenous immunoglobulin (IVIg) therapy; Physiotherapy; Like GBS, CIDP can improve spontaneously; However, recovery may be very slow and the illness can either get progressively better or worse, or can follow a relapsing/remitting course; Most patients with GBS (Guillian Barre" Syndrome) and CIDP are treated with plasmapheresis or immunoglobulin; Corticosteroids may be used to treat CIDP but are not used to treat GBS, as it worsens rather than improves the condition;

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External Links Related to Chronic Inflammatory Demyelinating Polyneuropathy (CIDIP)
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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