Disease Information for Cholinesterase inhibitor poison/exposure

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Clinical Manifestations
Signs & Symptoms
Chest Pain
Chest pain, substernal/midline
Dizzy on Standing/Giddy Response
Non-Pleuritic Chest Pain
Orthostatic drop in blood pressure
Slow pulse/Bradycardia
Diaphoresis profuse/active sweating/acute
Excess Sweating Children
Hyperhidrosis/Chronic sweating excess
Sweating Excess Perspiration
Abdominal Pain
Abdominal Pain Crampy
Active Bowel Sounds
Borborygmi/Bowel sound increased
Diarrhea
Diarrhea, explosive
Diarrhea, fulminant
Hypereactive Bowel Sounds
Loss of bowel control/incontinence acute
Nausea
Painful vomiting
Vomiting
Drooling
Excess salivation/hypersalivation
Foaming/Frothing at the mouth
Sialorrhea/Ptyalism
Cramping in Extremities
Hypertonia
Muscle cramps/spasms
Myokimia/Muscle pulling sensation
Weak/Weak as a kitten (symptom)
Active reflexes
Fatigability
Hyperreflexia/DTRs increased
Seizures
Spasms in Both Legs
Weakness/Diffuse motor loss
Bronchorrhea/excess watery sputum
Bronchospasm signs
Chest tightness/breathing response
Cough
Dyspnea
Shortness of breath/SOB
Sputum/pink frothy
Wheezing
Coryza
Runny nose/rhinorrhea
Acutely ill patient/signs
Constitutional symptoms
Enervated/extreme acute fatigue
Fatigue
Fatigue Tiredness Exhaustion
Weakness
Weakness non-neuromuscular/systemic
Lacrimation/excess tearing
Miosis/narrow pupils
Night blindness/Impaired night vision
Pupil Abnormal/Signs
Tearing
Typical Clinical Presentation
Coma with cholinergic ( SLUD) signs
Clinical Presentation & Variations
Presentation/Back pain Hyperreflexia Incontinence
Laboratory Tests
Abnormal Lab Findings - Decreased
Cholinesterase, serum (Lab)
Abnormal Lab Findings - Increased
RBC Actylcholinesterase level (Lab)
Diagnostic Test Results
EKG (ECG)
EKG/Widened QRS pattern (ECG)
EKG/Sinus bradycardia (ECG)
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Rule Outs
Botulism
Associated Disease & Complications
Acute respiratory failure/Respiratory arrest
Asthma
Brady-arrhythmia
Cholinergic crisis/toxidrome
Convulsions (grand mal)
Orthostatic syncope Hypotension
Sinus bradycardia
Disease Mechanism & Classification
Drugs
DRUG/Acetylcholinesterase inhibitor
DRUG/Cholinergic agonist drug/effect (example)
DRUG/Nicotinic cholinergic effects
DRUG/Parasympatheticomemitic effect (ex)
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/Peristalsis increased
Pathophysiology/Neuromuscular irritability
Pathophysiology/Bronchospasm
Pathophysiology/Tissue hypoxia/potential
Process
PROCESS/Poison/specific (category)
Toxin
TOXIN/AntiCholinesterase effect/anti-ACh
TOXIN/Decreases Heart Rate
TOXIN/SLUD response(sial/lacr/urine/dia)
Treatment
Drug Therapy - Indication
RX/Pralidoxime (Protopam)
Definition

Nerve gas, organophosphate,carbamat insecticides are

examples of usually well absorbed poison on skin contact.

often occupational farming exposures.

(Edit)

External Links Related to Cholinesterase inhibitor poison/exposure
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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