Disease Information for Cholinergic drug Administration/Toxicity/effect

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Clinical Manifestations
Signs & Symptoms
Dizzy on Standing/Giddy Response
Orthostatic drop in blood pressure
Slow pulse/Bradycardia
Diaphoresis profuse/active sweating/acute
Excess Sweating Children
Hyperhidrosis/Chronic sweating excess
Sweating Excess Perspiration
Active Bowel Sounds
Borborygmi/Bowel sound increased
Diarrhea
Diarrhea, explosive
Diarrhea, fulminant
Nausea
Vomiting
Drooling
Excess salivation/hypersalivation
Foaming/Frothing at the mouth
Sialorrhea/Ptyalism
Hypertonia
Muscle cramps/spasms
Twitchy/muscle spasms
Active reflexes
Hyperreflexia/DTRs increased
Seizures
Bronchospasm signs
Dyspnea
Wheezing
Coryza
Runny nose/rhinorrhea
Lacrimation/excess tearing
Night blindness/Impaired night vision
Pupil Response to Darkness Poor
Tearing
Typical Clinical Presentation
Coma with cholinergic ( SLUD) signs
Demographics & Risk Factors
Established Disease Population
Patient/On Medications long term/ usually
Patient/Myasthenia gravis/on treatment
Sex & Age Groups
Population/Adult/all
Laboratory Tests
Abnormal Lab Findings - Increased
Lipase (Lab)
Diagnostic Test Results
EKG (ECG)
EKG/Widened QRS pattern (ECG)
EKG/AV Nodal Block/Complete
EKG/Sinus bradycardia (ECG)
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Associated Disease & Complications
Acute gastroenteritis
Asthma
Brady-arrhythmia
Bradyarrhythmias
Cardiac conduction defects
Cholinergic crisis/toxidrome
Convulsions (grand mal)
Drug induced Bronchospasm/asthma
Gastroenteritis, acute infectious
Heart block, complete
Orthostatic syncope Hypotension
Sinus bradycardia
Tachyarrhythmia
Disease Mechanism & Classification
Drugs
DRUG/Cholinergic agonist drug/effect (example)
DRUG/Enteric/gut motor stimulation
DRUG/Nicotinic cholinergic effects
DRUG/Parasympatheticomemitic effect (ex)
DRUG/Reaction to medication/drug induced (ex)
DRUG/Lowers seizure threshold
DRUG/Group term or type of medication
Pathophysiology
Pathophysiology/Acetyl choline accumulation
Pathophysiology/Peristalsis increased
Pathophysiology/Neuromuscular irritability
Pathophysiology/Bronchospasm
Pathophysiology/Excess bronchial secretions
Process
PROCESS/Drug induced disorder (ex)
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Decreases Heart Rate
TOXIN/SLUD response(sial/lacr/urine/dia)
Definition

Anticholinesterase drug effects; usually used in myasthenia gravis or belladonna type poisoning

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External Links Related to Cholinergic drug Administration/Toxicity/effect
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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