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- Disease Information
- Disease Comparison
-
Disease Processes ▼
- Auto Immune
- Vascular-Arteriosclerosis
- Biochemical
- Congenital-developmental
- Deficiency
- Degenrative-Necrosis
- Electromagnetic-Physics
- Eponymic
- Functional-Physiologic
- Hereditofamilial
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- Idiopathic
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- Infectious agent
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- Poisoned Organ
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- Trauma
- Use-age-Atrophic
- Endocrine-Vegetative
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Major Organs-Systems ▼
- Systemic
- Pediatric
- Nervous & Sensory System (Neurology)
- Cardiovascular System
- Respiratory (Pulmonary) System
- Gastro-Intestinal (Digestive) System
- Urinary System
- Dermatologic System
- Endocrine System
- Immune System
- Musculoskeletal System
- Genital Reproductive System
- Hematopoietic System (Hematology)
- Lymphatic System
- Tissue/Cells/Organelles
Disease Information for Chlorambucil (Leukeran) Administration/Toxicity
- Clinical Manifestations
- Signs & Symptoms
- Baldness/Alopecia
- Hair loss
- Non-scarring Alopecia/balding
- Seizures
- Laboratory Tests
- Abnormal Lab Findings (Non Measured)
- Chronic lymphopenia
- Abnormal Lab Findings - Decreased
- Lymphocytes (Lab)
- Neutrophiles (Lab)
- Abnormal Lab Findings - Increased
- Acute lymphopenia/transient
- Platelet count (Lab)
- Azospermia
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Acute Myelogenous/Myeloblastic Leukemia AML
- Agranulocytosis
- Anemia
- Bone marrow failure/exhaustion
- Convulsions (grand mal)
- Drug induced Anemia.
- Drug induced Baldness/Alopecia
- Drug induced Hepatic toxicity
- Drug induced Lung disease.
- Drug induced Myelosuppression.
- Drug induced Neutropenia.
- Drug induced Seizures
- Drug induced Thrombocytopenia.
- Fetal anomaly
- Fetal damage/teratogenic effect
- Granulocytopenia/Neutropenia
- Infertility/sterility male
- Infertility/sterility, female
- Lymphocytopenia
- Myelodysplasia
- Myelosuppression
- Thrombocytopenia
- Thrombocytosis
- Toxic hepatitis
- Disease Mechanism & Classification
- Drugs
- DRUG/Active metabolites
- DRUG/Alkylating agents (example)
- DRUG/Carcinogenic potential
- DRUG/Chemotherapeutics/cancer drugs/etc (category)
- DRUG/Impaired DNA metabolism effect/drug (example)
- DRUG/Late leukemia/lymphoma complication
- DRUG/Nitrogen mustard alkylating agent
- DRUG/Oral Anti-cancer drug (ex)
- DRUG/Plasma protein/albumin bound
- DRUG/Prevents transplant/allograft rejection
- DRUG/Teratogenic potential/effect (D plus )
- DRUG/Lowers seizure threshold
- Pathophysiology
- Pathophysiology/Myelodysplasia process
- Synonyms
- Synonym
- 4 (Bis(2 chloroethyl)amino)benzenebutanoic Acid, 4 (p (Bis(2 chloroethyl)amino)phenyl)butyric acid, Benzenebutanoic acid, 4 (bis(2 chloroethyl)amino), Benzenebutanoic acid, 4 (bis(2 chloroethyl)amino) (9CI), Butyric acid, 4 (p (bis(2 chloroethyl)amino)phenyl), butyric acid, 4 (p bis(2 chloroethyl)aminophenyl), CBL, CHL, Chlorambucil, Chlorambucil (product), Chlorambucil (substance), CHLORAMBUCIL PREPARATION, Chlorambucilum, Chloraminophen, Chloraminophene, Chlorbutin, Chlorbutine, chlorbutinum, Chloroambucil, Chlorobutin, Chlorobutine, CLB, gamma (p bis(2 chloroethyl)aminophenyl)butyric acid, gamma (p di(2 chloroethyl)aminophenyl)butyric acid, N,N Di (2 chloroethyl) p aminophenylbutyric Acid, N,N Di 2 chloroethyl gamma p aminophenylbutyric acid, p (N, N di 2 chloroethyl)aminophenyl butyric acid, p N, N Di ( beta chloroethyl)aminophenyl butyric acid, p N, N di (beta chloroethyl)aminophenyl butyric acid, para N,N di(b chloroethyl)aminophenylbutyric acid, Phenylbutyric acid nitrogen mustard, Brand name/Leukeran (Chlorambucil)
- Treatment
- Drug Therapy - Contraindication
- RX/Alkylating agents
- Drug Dosage
- DRUG/.1990 or before
- DRUG/Dose 2 mgm (Unit/Pill/Capsule size)
- DRUG/Dose must be titrated to effect
- DRUG/Dose once daily (RX)
- DRUG/Injection Preparation NOT available
- DRUG/Oral medication (ex)
- -Pro-drug pharmacology
- Definition
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Primarily an Antineoplastic cancer chemotherapy drug. Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell division. Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often.
(Edit)
- External Links Related to Chlorambucil (Leukeran) Administration/Toxicity
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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