Disease Information for Chlorambucil (Leukeran) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Baldness/Alopecia
Hair loss
Non-scarring Alopecia/balding
Seizures
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Chronic lymphopenia
Abnormal Lab Findings - Decreased
Lymphocytes (Lab)
Neutrophiles (Lab)
Abnormal Lab Findings - Increased
Acute lymphopenia/transient
Platelet count (Lab)
Azospermia
Associated Diseases & Rule outs
Associated Disease & Complications
Acute Myelogenous/Myeloblastic Leukemia AML
Agranulocytosis
Anemia
Bone marrow failure/exhaustion
Convulsions (grand mal)
Drug induced Anemia.
Drug induced Baldness/Alopecia
Drug induced Hepatic toxicity
Drug induced Lung disease.
Drug induced Myelosuppression.
Drug induced Neutropenia.
Drug induced Seizures
Drug induced Thrombocytopenia.
Fetal anomaly
Fetal damage/teratogenic effect
Granulocytopenia/Neutropenia
Infertility/sterility male
Infertility/sterility, female
Lymphocytopenia
Myelodysplasia
Myelosuppression
Thrombocytopenia
Thrombocytosis
Toxic hepatitis
Disease Mechanism & Classification
Drugs
DRUG/Active metabolites
DRUG/Alkylating agents (example)
DRUG/Carcinogenic potential
DRUG/Chemotherapeutics/cancer drugs/etc (category)
DRUG/Impaired DNA metabolism effect/drug (example)
DRUG/Late leukemia/lymphoma complication
DRUG/Nitrogen mustard alkylating agent
DRUG/Oral Anti-cancer drug (ex)
DRUG/Plasma protein/albumin bound
DRUG/Prevents transplant/allograft rejection
DRUG/Teratogenic potential/effect (D plus )
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/Myelodysplasia process
Synonyms
Synonym
4 (Bis(2 chloroethyl)amino)benzenebutanoic Acid, 4 (p (Bis(2 chloroethyl)amino)phenyl)butyric acid, Benzenebutanoic acid, 4 (bis(2 chloroethyl)amino), Benzenebutanoic acid, 4 (bis(2 chloroethyl)amino) (9CI), Butyric acid, 4 (p (bis(2 chloroethyl)amino)phenyl), butyric acid, 4 (p bis(2 chloroethyl)aminophenyl), CBL, CHL, Chlorambucil, Chlorambucil (product), Chlorambucil (substance), CHLORAMBUCIL PREPARATION, Chlorambucilum, Chloraminophen, Chloraminophene, Chlorbutin, Chlorbutine, chlorbutinum, Chloroambucil, Chlorobutin, Chlorobutine, CLB, gamma (p bis(2 chloroethyl)aminophenyl)butyric acid, gamma (p di(2 chloroethyl)aminophenyl)butyric acid, N,N Di (2 chloroethyl) p aminophenylbutyric Acid, N,N Di 2 chloroethyl gamma p aminophenylbutyric acid, p (N, N di 2 chloroethyl)aminophenyl butyric acid, p N, N Di ( beta chloroethyl)aminophenyl butyric acid, p N, N di (beta chloroethyl)aminophenyl butyric acid, para N,N di(b chloroethyl)aminophenylbutyric acid, Phenylbutyric acid nitrogen mustard, Brand name/Leukeran (Chlorambucil)
Treatment
Drug Therapy - Contraindication
RX/Alkylating agents
Drug Dosage
DRUG/.1990 or before
DRUG/Dose 2 mgm (Unit/Pill/Capsule size)
DRUG/Dose must be titrated to effect
DRUG/Dose once daily (RX)
DRUG/Injection Preparation NOT available
DRUG/Oral medication (ex)
-Pro-drug pharmacology
Definition

Primarily an Antineoplastic cancer chemotherapy drug. Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell division. Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often.

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External Links Related to Chlorambucil (Leukeran) Administration/Toxicity
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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